Result: A new vaccine therapeutic intervention is thus needed for Surat isolate as it harbors a potential mutation (P1089V) in its spike protein.

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Result: Besides, a rare mutation (P1089V) is identified in the spike protein of Surat isolate (GBRC275b).

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Discussion: Genome variation analysis found a rare mutation, P1089V in the spike protein of Surat (GBRC275b) isolate, reflecting its clinical importance in COVID-19 patients.

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