literature

SARS_CoV_2 mutation literature information.

Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.

PMID: 34880635 2021 Infection and drug resistance

Table: N679K

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection.

PMID: 34909788 2021 medRxiv

Method: P2 stock was sequenced and confirmed Omicron with the following substitutions: E:T9I,M:D3G,M:Q19E,M:A63T,N:P13L,N:R203K,N:G204R,ORF1a:K856R,ORF1a:L2084I,ORF1a:A2710T,ORF1a:T3255I,ORF1a:P3395H,

PMID: 34931200 2021 medRxiv

Introduction: The Omicron spike in this study contained mutations A67V, Delta69-70, T95I, G142D, Delta143-145, Delta211, L212I, +214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K,

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity.

PMID: 34960755 2021 Viruses

Result: Furthermore, continued surveillance is necessary as several independent lineages have recently emerged containing additional substitutions proximal to S1/S2 cleavage junction, such as the B.1.2 and B.1.525 with Q677H, C.37 and B.1.617.2 with Q675H, and C.1.2 with N679K substitutions.

Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR(-/-) mice.

PMID: 33015402 2020 Heliyon

Result: Likewise, the polybasic cleavage site (RRAR) and neighboring amino acids (positions 667-694) were retained, except for the single N679K substitution.

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