Result: The spike protein substitutions observed in C.1.2 include five within the N-terminal domain (NTD: C136F, Y144del, R190S, D215G, and 242-243del or 2
Result: The majority of these substitutions (P9L, C136F, R190S, D215G, L242del, A243del, Y449H, E484K, N501Y, H655Y, and T716I), however, appeared simultaneously, further supporting a single, prolonged infection giving rise to this lineage.
The basis of mink susceptibility to SARS-CoV-2 infection.
Introduction: In the mouse model, the N501Y mutation has been associated with increased infectivity and virulence of SARS-CoV-2 (Gu et al.).
Introduction: Nowadays, the N501Y mutation characterizes the novel SARS-CoV-2 variant from the UK named VOC202012/01 (B.1.1.7) (European Centre for Disease Prevention and Control), which was recently detected in Poland (Hryhorowicz et al.).
Introduction: Some of these mutations, such as the 69-70 deletion in combination with the N501Y variant, increase the transmissibility of SARS-CoV-2.
Introduction: The RBD included 44 mutation sites, in which the S77N, V483A, A344S, and N501Y mutations were the most frequent, while the Y453, G476, F486, T500, and N501 mu
Dynamic Ca(2+) sensitivity stimulates the evolved SARS-CoV-2 spike strain-mediated membrane fusion for enhanced entry.
Result: This could be due to enhanced binding of RBD of B.1.1.7 with ACE2 due to N501Y mutation, which enhances receptor recognition and fusion, or simply due to enhanced triggering, consistent with previous data.
Inhibitor screening using microarray identifies the high capacity of neutralizing antibodies to Spike variants in SARS-CoV-2 infection and vaccination.
Result: An additional five mutations had <= 2-fold increased binding to human ACE2 (Figure 2C-D): L452R (in B.1.427/429 and B.1.617), Y453F (in B.1.1.298), E484Q (in B.1.617.1 and B.1.617.3) and N501Y (in B.1.1.529, B.1.1.7, B.1.351 and P.1).
Result: Notably, structural analyses show that 5 escape mutations (K417N/E484K/N501Y, G446V, F456E, N487R, F490L) are located within the interface of RBD-ACE2 interaction, indicating that this RBD subdomain is important in neutralizing SARS-CoV-2 infection.
Result: The most prevalen
Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern.
Method: On deep sequencing following amino acid changes were found in the isolate.(NSP5_P132H,Spike_T95I,Spike_K417N,Spike_S373P,Spike_Q493R,Spike_N969K, Spike_H655Y,Spike_
Discussion: It harbours N501Y, K417N, T478K, E484A which are amino acid substitutions linked with immune escape.
Molecular Dynamics and MM-PBSA Analysis of the SARS-CoV-2 Gamma Variant in Complex with the hACE-2 Receptor.
Introduction: Additionally, the mutation N501Y exhibits a compensatory effect since it favors pi-pi interaction with the residue Y41.
Introduction: The alpha variant has three mutations of interest in the spike protein: (i) the N501Y mutation that corresponds to the receptor-binding motif (RBM); (ii) a 69/70 deletion in the receptor binding domain (RBD) that triggers a notable change in the conformation of the RBM; and (iii) the P681H mutation found near the furin S1/S2 cleavage site.
Introduction: The beta variant, also known as 20H/501Y.V2, was identified in South Africa and is characterized by carrying the K417N, E484K and N501Y mutations in the RBM of the
Increased Secondary Attack Rate among Unvaccinated Household Contacts of Coronavirus Disease 2019 Patients with Delta Variant in Japan.
PMID: 35409572
2022
International journal of environmental research and public health
Abstract: We studied household contacts of index cases of COVID-19 infected with Delta (L452R mutation), Alpha (N501Y mutation), and wild strain from December 2020 through November 2021 in Itako, Japan.
Method: Almost all cases with the N501Y mutation during the study period in Japan were confirmed to be the Alpha variant by RNA sequencing.
Method: Contact with the Alpha strain was defined as contact of the index patient with positive results for N501Y mutation until 20 June 2021 or negative results for L452R mutation after 21 June 2021 among the patient, or the patient's contacts.
Method: If the index case was reported after 22 March, and both N501Y and L452R mutation screening were not p
Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and India.
PMID: 35427787
2022
Infection, genetics and evolution
Discussion: N501Y, D614G L452R, and E484Q mutations are reported as significant mutations in different variants in SARS-CoV-2.
Discussion: Finally, we evaluated the comparative receptor binding (hACE2) pattern with the Wuhan strain, VOC B.1.1.7 variant (RBD N501Y mutatio
Discussion: The variant was observed with some significant mutations in spike protein.Comparative genomics assessment of these two variants has revealed specific unique mutations, such as N501Y, D614G L452R, E484Q, and P681R in the S-glycoprotein.
Role of the Microbiome in the Pathogenesis of COVID-19.
PMID: 35433495
2022
Frontiers in cellular and infection microbiology
Conclusion: The neutralization resistance occurred due to E484K and N501Y mutations in the RBD of the spike.
Introduction: These were the N501Y (asparagine to tyrosine substitution at position 501 in the S gene) and the 69-70del (a deletion of 6 bases coding for histidine and valine at positions 69 and 70 in the S gene) mutations.
Introduction: This variant has the same mutation N501Y like the UK variant; however, the two variants are phylogenetically not related 4 .
Table: N501Y
Antigenicity comparison of SARS-CoV-2 Omicron sublineages with other variants contained multiple mutations in RBD.
Result: The RBD contains three mutations, which are Y449H, E484K, and N501
Result: The B.1.640.1 variant contains 22 mutations in spike protein, of which the RBD contains five mutations of R346S, N394S, Y449N, F490R, and N501Y.
Discussion: The immunogenicity of Beta, Gamma, and Mu were similar, probably because these three immunogens all contained E484K and N501Y mutations (Figure S1).
Discussion: The neutralizing activity of mAb JS016 was reduced due to the N501Y mutation in the variants.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Nature communications
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