Introduction: Few mutations include K417T/N, E484K, L452R, N501Y, P681R, D614G, etc.
Introduction: In this direction, we illustrated the mutations in the
Introduction: developed pseudoviruses with different RBD mutations or other parts of S-glycoprotein such as N501Y, K417N/T, and E484K, to illustrate the neutralization event.
Method: The N501Y mutation is noted in the Omicron along with other variants.
Table: N501Y
Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2.
Abstract: We found that the Mu variant and a derivative of the Delta strain with E484K and N501Y mutations significantly evaded vaccine-elicited neutralizing antibodies.
Result: Delta + E484K + N501Y and Mu showed a pattern similar to that of Beta, with 73.8% and 78.6% of the samples strongly neutralized, respectively.
Result: Delta + E484K + N501Y was detected only i
Discussion: In particular, only about 15-30% of vaccinees showed potent neutralizing activity against Delta, Delta + E484K + N501Y, and Mu strains.
Discussion: The N501Y mutation was common in the strains with reduced efficacy, suggesting that this mutation is a limitation of etesevimab.
Variants of SARS CoV-2: mutations, transmissibility, virulence, drug resistance, and antibody/vaccine sensitivity.
PMID: 35227008
2022
Frontiers in bioscience (Landmark edition)
Abstract: N501Y is a mutation in the receptor binding domain of the S protein that increases binding to the ACE-2 receptor on the human host cells by 10 fold.
SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity.
Method: For ELISA, ADCP and ADCD assays, SARS-CoV-2 original and Beta variant full spike (L18F, D80A, D215G, K417N, E484K, N501Y, D614G, A701V, 242-244 del), RBD original and Beta (
Result: As for full spike (Figure S1), CR3022 ADCC against the RBD was unaffected by Beta RBD mutations (K417N, E484K, and N501Y), while ADCC mediated by P2B-2F6 was abrogated (Figure 3A).
Table: N501Y
Rapidly Identifying New Coronavirus Mutations of Potential Concern in the Omicron Variant Using an Unsupervised Learning Strategy.
Abstract: To build an investigative framework, we have applied an unsupervised machine learning approach to 4296 Omicron viral genomes collected and deposited to GISAID as of December 14, 2021, and have identified a core haplotype of 28 polymutants (A67V, T95I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H,
Age-Specific Changes in Virulence Associated with SARS-CoV-2 Variants of Concern.
Introduction: As such, it has been challenging to determine with certainty whether infection with the Delta VOC is more virulent in children than non-VOC SARS-CoV-2 or other VOCs, such as those with the N501Y mutation.
Introduction: In the Canadian province of Ontario, the VOC carrying the N501Y mutation (including the Alpha/B.1.1.7, Beta/B.1.351, and Gamma/P.1 VOC) replaced earlier SARS-CoV-2 lineages by April 2021 but were, in turn, replaced by the Delta (B.1.617.2) variant, which has been the dominant variant in the province since July 2021.
Introduction: Our objectives were to estimate age-specific risks of severe illness in individuals infected with the Delta or N501Y-positive VOC relative to non-VOC SARS-CoV-2 infection, determine whether there is heterogeneity in differential risk by age group, and explore the possible sources of an
Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.
Discussion: S477N, T478K, and E484A were initially at ~47% (status 2021-12-14, 2146 sequences), now instead above 88%, as N501Y (status 2022-02-07, 873.492 sequences).
Discussion: Several Omicron RBD mutations are assumed to increase the binding to ACE2: G339D, S477N, T478K, Q493K, and N501Y; others are proposed to be neutral: S371L, S373P, G446S, E484A, Q493R, and Q498R, or are assumed to reduce the binding to ACE2: PMID: 35240804
2022
Mathematical biosciences and engineering
Abstract: The variant of concern (VOC) 202012/01 (B.1.1.7, also known as the alpha variant) bearing the N501Y mutation emerged in late 2020.
Antibody escape and global spread of SARS-CoV-2 lineage A.27.
Abstract: Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G.
Result: L18F is present in the VOCs B.1.351 and P.1, the L452R substitution is found in high frequencies in B.1.617.2 and related AY lineages, and N501Y is known from B.1.1.7, B.1.351 and P.1.
Result: Furthermore, N501Y was suggested to enhance the binding affinity to ACE2.
Result: Lineage A.27 has two mutations in its Table: N501Y
Evolution of the SARS-CoV-2 spike protein in the human host.
Abstract: Spikes of both variants have the same mutation, N501Y, in the receptor-binding domains.
Method: The following variant spikes were made (SA, Alpha and mink) (all mutations listed with reference to the NCBI sequence YP_009724390.1): 2P Alpha (Delta69-70, Delta144, N501Y, A570D, D614G, P681H, T716A, S982A, D1118H, and K986P, V987P), FUR2P Alpha (Delta69-70, Delta144,
Figure: d The N501Y substitution present in both the Beta and Alpha variants allows formation of a new hydrogen bond or a salt bridge.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Frontiers in immunology
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