Result: 44 years (IQR 29-60; N501Y negative); at Bioanalytica the median age was 43 years (IQR 29-53; N501Y positive) vs.
Result: 48 years (IQR 32-67; N501Y negative); and at Viollier AG the median age was 41 years (IQR 26-54; N501Y positive) vs.
Result: A total of 739 S:N501Y-carrying (B.1.1.7 n = 675, and B.1.351 n = 53; P.1 n = 11) Swiss high quality genomes were available for phylogenetic analysis.
Result: At the University Hospital Basel the median age of patients with N501Y positive was 34 years (IQR 12-47) whereas the median age of patients with N501Y negative was 38 years (27-54); at the University
Molecular Analysis of SARS-CoV-2 Genetic Lineages in Jordan: Tracking the Introduction and Spread of COVID-19 UK Variant of Concern at a Country Level.
Method: The measurement of within-lineage genetic distances was done using MEGA6, which was also used to detect the following amino acid substitutions/deletions in the spike glycoprotein sequence: D614G, E484K, N501Y, P681H, 69-70del, and K417N.
Result: The amino acid substitutions N501Y and P681H besides the deletion Delta69/70 were consistently found among the lineage B.1.1.7 sequences, while
Discussion: This proposed change in virus behavior can be related to enhanced binding between the spike glycoprotein of this lineage and its receptor; and this enhancement has been proposed to be the result of N501Y amino acid substitution.
Method: B.1.1.7 virus contained the following spike mutations: del-H69-V70, del-Y144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H.
Method: B.1.351 virus contained the following spike mutations: L18F, D80A, D215G, del-L242_244, R246I, K417N, E484K, N501Y, D614G, A701V.
Table: N501Y
Comparison of Clinical Features and Outcomes of Medically Attended COVID-19 and Influenza Patients in a Defined Population in the 2020 Respiratory Virus Season.
Introduction: Such SARS-CoV-2 variants include the 20I/501Y.V1, 20 H/501Y.V2, and 20 J/501Y.V3 strains that harbor a N501Y substitution in the spike RBD and were reported in the UK and in South Africa, as highly transmissible, and in Brazil, respectively.
Result: Thirdly, we tested 26 samples identified by next-generation genome sequencing as containing SARS-CoV-2 strains that were not Marseille-4 variants (including 17 N501Y variants, 5 Marseille-2 variants, 3 clade 20A strains and 1 clade 20C strain): none of them were positive using our Marseille-4 specific qPCR.
AutoVEM: An automated tool to real-time monitor epidemic trends and key mutations in SARS-CoV-2 evolution.
PMID: 33841748
2021
Computational and structural biotechnology journal
Discussion: Among them, the frequency of N501Y mutation seems to reach 10% in the latest 28 days (13/11/2020-10/12/2020), whether the frequency of the mutation will increase over time should be monitored to further infer the significance of the mutation.
Discussion: In addition, previous researchers identified several other mutations of N439K, Y453F and N501Y in the S protein, but we did not.
Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016.
Result: have reported that E484K and K417N dramatically and specifically reduce neutralization by LY-CoV555 and LY-CoV016, respectively, while N501Y has no impact on neutralization by either antibody.
Figure: (B) Literature measurements of the effects of K417N, E484K, and N501Y on neutralization by LY-CoV555 and LY-CoV016.
Figure: These measurements validate our maps, which suggest that K417N specifically escapes LY-CoV016, E484K specifically escapes LY-CoV555, and N501Y affects neither antibody.
Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike.
Introduction: N501Y has subsequently been found in other VOCs circulating around the world, i.e., B.1.351 and B.1.1.28.1 (P.1)
Introduction: N501Y has subsequently been found in other VOCs circulating around the world, i.e., B.1.351 and B.1.1.28.1 (P.1).
Introduction: Of particular note were nine mutations in the spike gene compared to prototype sequences; a 69-70 deletion (the cause of S-gene target failure), Y144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D118H, with seven of these distinct to B.1.1.7.
Introduction: One of the more concerning
A new SARS-CoV-2 lineage that shares mutations with known Variants of Concern is rejected by automated sequence repository quality control.
Abstract: We report a SARS-CoV-2 lineage that shares N501Y, P681H, and other mutations with known variants of concern, such as B.1.1.7.
Result: Specifically, N501Y is thought to be important for viral replication because it enables the virus to bind ACE2 and enter host cells more efficiently.
Result: Specifically, each sample contains Spike mutations S494P, N501Y, D614G, P681H, K854N, and E1111K.
Result: Compared to the Wuhan sequence, P.1 contains the following mutations: L18F, T20N, P26S, D138Y, and R190S in the NTD; K417T, E484K, and N501Y in the RBD; D614G and H655Y at the C terminus of S1; and T1027I and V1176F in S2.
Result: Here, we have expressed P.1 RBD (K417T, E484K, and N501Y).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Microorganisms
Browser Board
Co-occurred Entities
Filtrator
ViMRT