Introduction: For instance, the K417N and N501Y mutations were known to confer protection against a number of mAbs.
Introduction: Furthermore, consistent with the observations highlighted above, the Q498R substitution may act synergistically with the existing N501Y substitution to increase the affinity of the spike protein to ACE2.
Introduction: Interestingly, the presence of the K417N mutation did not affect spike-ACE2 binding affinity but produced positive cooperativity with E484K/N501Y.
Introduction: One example is the N501Y mutation, shared by Alpha, Beta, and Gamma variants, which enhances the binding of
Omicron Variant of SARS-CoV-2 Virus: In Silico Evaluation of the Possible Impact on People Affected by Diabetes Mellitus.
Introduction: Some of these mutations, such as Q498R and N501Y, have already proven to lead to an increased affinity with ACE2 in respect to WT-Spike.
Discussion: This variation, together with several mutations on Spike-RBD that were linked to an increased affinity for ACE2 (such as S477N, Q498R, and N501Y), is predicted to contribute to an increase in the interactivity between Omicron-Spike-RBD and ACE2 in a hyperglycemic environment.
First detection of SARS-CoV-2 lineage A.27 in Sardinia, Italy.
PMID: 35324468
2022
Annali dell'Istituto superiore di sanita
Abstract: Among the key mutations identified in the spike protein, the N501Y and the L452R deserve attention as considered likely vaccine escape mutations.
Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds.
Result: Finally, 1/32 sequence was the Omicron strain, with the following mutations in the RBD domain: T22882G (N440K), G22898A (G446S), G22992A (S477N), C22995A (T478K), A23013C (E484A), A23040G (Q493R), G23048A (G496S), A23055G (Q498R), A23063T (N501Y), T23075C ( PMID: 35454161
2022
Biomolecules
Abstract: Our calculations show that five major mutations (N501Y, E484K, L452R, T478K and K417N), first reported in Alpha, Beta, Gamma an
Introduction: As shown in Table 1, these three variants have one point in common:that is, the N501Y mutation, which was reported to accelerate the spread of virus through stronger binding with ACE2.
Introduction: We first focus on five specific mutations (N501Y, E484K, L452R, T478K and K417N) that were found in Alpha, Beta Gamma and Delta variants, and these mutations are all located on the RBDs of the SARS-CoV-2/ACE2 complex.
Antigenicity comparison of SARS-CoV-2 Omicron sublineages with other variants contained multiple mutations in RBD.
Result: The RBD contains three mutations, which are Y449H, E484K, and N501
Result: The B.1.640.1 variant contains 22 mutations in spike protein, of which the RBD contains five mutations of R346S, N394S, Y449N, F490R, and N501Y.
Discussion: The immunogenicity of Beta, Gamma, and Mu were similar, probably because these three immunogens all contained E484K and N501Y mutations (Figure S1).
Discussion: The neutralizing activity of mAb JS016 was reduced due to the N501Y mutation in the variants.
Characteristic analysis of Omicron-included SARS-CoV-2 variants of concern.
Result: The scores of E484K and N501Y are also relatively close, indicating that these mutations do not affect the epitope of the spike protein of the Beta strain (Figure 2E).
Discussion:
Discussion: In the Alpha and Omicron strains, two key deletions, H60V70, are on the epitope, which can affect the immune escape of the S protein (Figure 4F), whereas N501Y and D614G have almost no effect on the antigen score, and the P681 mutation slightly reduces the epitope score and may have a certain impact.
Discussion: In the Omicron variant, there are some consistent RBD mutations with previously focused variants (K417N, T478K, and N501Y).
Role of the Microbiome in the Pathogenesis of COVID-19.
PMID: 35433495
2022
Frontiers in cellular and infection microbiology
Conclusion: The neutralization resistance occurred due to E484K and N501Y mutations in the RBD of the spike.
Introduction: These were the N501Y (asparagine to tyrosine substitution at position 501 in the S gene) and the 69-70del (a deletion of 6 bases coding for histidine and valine at positions 69 and 70 in the S gene) mutations.
Introduction: This variant has the same mutation N501Y like the UK variant; however, the two variants are phylogenetically not related 4 .
Table: N501Y
Comparative Evaluation of Six SARS-CoV-2 Real-Time RT-PCR Diagnostic Approaches Shows Substantial Genomic Variant-Dependent Intra- and Inter-Test Variability, Poor Interchangeability of Cycle Threshold and Complementary Turn-Around Times.
Discussion: In addition, variant B.1.258.17 as the main lineage during the second wave, variant A.27 as a rare variant, with mutation N501Y, and variant B.1 (with D614G) as the first main lineage, which caused a substantial part of the first wave of infections in Europe, were included.
SARS_CoV_2 mutation literature information.
PMID: 
2022
MedComm
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