Impact of B.1.617 and RBD SARS-CoV-2 variants on vaccine efficacy: An in-silico approach.
PMID: 35370005
2022
Indian journal of medical microbiology
Table: N501T
Discussion: A few mutants' viz.L455Y, Q493N, R408I, Q498Y, F486L, N501T within the RBD region (319-591), and D936Y& A930V within HR1 site (912-984) have also been studied by in silico analysis to investigate the basic structure of spike glycoprotein.
The basis of mink susceptibility to SARS-CoV-2 infection.
Figure: Abbreviations stand for: CT, cytoplasmic domain; D614G, mutation in the S protein; F486L, mutation in the S protein; FP, fusion peptide; HR1, heptapeptide repeat sequence 1; HR2, heptapeptide repeat sequence 2; N501T, mutation in the S protein; NDT, N-terminal domain; PRRA, polybasic cleavage site; RBD, receptor-binding domain; S1, S1 subunit of the S protein; S2, S2 subunit of the S protein; TM, transmembrane domain; Y453F, mutation in the S protein.
Discussion: According to Welkers et al., each of the three mut
Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2.
PMID: 34957216
2021
Frontiers in molecular biosciences
Result: In contrast, N501T, on the SARS-CoV-2 decreasedG by -1.346 kcal/mol.
Table: N501T
Discussion: A previous study performed deep mutation scanning on SARS-CoV-2 identified N501T as a binding affinity enhancer.
Discussion: Interestingly, T487N decrease the binding affinity of SARS-CoV-1, while N501T increase the binding affinity of SARS-CoV-2 (Table 1).
Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay.
Introduction: The lineages P.2, P.4, and P.5, carrying the concerning amino acid changes S:E484K, S:L452R, and S:E484Q/N501T, respectively, were also initially detected in samples from Brazil.
Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.
Abstract: Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens.
Introduction: Alarmingly, N = 2122 N501T strains were posted to GISAID from specimens collected in the months that followed the identification of this specimen in Senegal (January-April 2021) from countries in Africa, Europe, Asia, North America, and South America (GISAID, date of accession April 18th, 2021).
Introduction: In addition to the L452R + N501Y double mutant, a single genome was identified that carried a unique combination of
Postvaccination SARS-COV-2 among Health Care Workers in New Jersey: A Genomic Epidemiological Study.
Result: To further characterize the SARS-CoV-2 genotypes recovered from the postvaccinated individuals, we examined the spread of key mutations underlying VOCs (i.e., B.1.1.7) in New Jersey using a high-throughput molecular beacon assay designed to screen for polymorphisms N501Y/T and E484K/Q in the receptor-binding domain (RBD) region.
An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms.
Result: A query of all GISAID sequences from Neovison vison viruses revealed that 95.4% had mutations D614G and N501T.
Result: One of the two mink from farm A had mutations at T85I-NSP2, S1205L-NSP3, G37E-NSP9, P323L-NSP12, T91M-NSP15, D614G-spike, N501T-spike, Q57H-NS3, H182Y-NS3, and T205I-N
Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.
Prediction of the Effects of Variants and Differential Expression of Key Host Genes ACE2, TMPRSS2, and FURIN in SARS-CoV-2 Pathogenesis: An In Silico Approach.
PMID: 34720581
2021
Bioinformatics and biology insights
Result: We also analyzed the effect of 27 missense variants of SARS-CoV-2 spike protein (RBD) on the binding interaction of spike protein with ACE2 and observed that L452Q, T478K, L455F, F456L, S459F, A475V, N439K, L452R, T470N, E484D, E484A, E484K, E484Q, F486L, S494P, S494L, N501T,
ViMRT
SARS_CoV_2 mutation literature information.
PMID: 
2022
Indian journal of medical microbiology
