Result: None of the 41 rare receptor binding variants described in GISAID-including the two most common, S477N and N439K -were observed in the Malaysian sequences.
Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants.
PMID: 33380328
2020
Journal of translational medicine
Result: On the other hand, the N439K is dominating the isolates landscape in Ireland and England from August 2020.
Result: The geographical distribution shows how the S477N variant is strongly rooted in Australia, and the N439K is associated with clusters starting from the United Kingdom (Scotland).
Result: The overall Epitope score, that takes into account a variable amino acid window surrounding the mutation, is slightly increased, from 0.535/0.516 in the WT sequence to 0.561 and 0.548 for S477N and N439K, respectively (Additional file 1: Table S5).
Result: When focusing to all the mutated epitopes caused by S477N and N439K, none cause a shift of the amino acid exposition, as they are both predicted to be in the exposed status.|
Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation.
SARS_CoV_2 mutation literature information.
PMID: 
2020
PLoS neglected tropical diseases
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