literature

SARS_CoV_2 mutation literature information.

Large scale genomic analysis of 3067 SARS-CoV-2 genomes reveals a clonal geo-distribution and a rich genetic variations of hotspots mutations.

PMID: 33170902 2020 PloS one

Result: The T265I, D614G and L84S hotspot mutations located in orf1ab and Spike proteins respectively were introduced into the virus for the first time in late February (Fig 4B).

Result: The most represented was D614G mutation at spike protein with 43.46% (n = 1.333) of the genomes, the second was L84S (at ORF8) found in 23.21% (n = 712).

Result: The second subclade SCB2 also stared in China at the beginning of Jan and harbored the mutation L84S (ORF8).

COVID-19 outbreak in Malaysia: Decoding D614G mutation of SARS-CoV-2 virus isolated from an asymptomatic case in Pahang.

PMID: 33329480 2020 Frontiers in microbiology

Result: Among the common variants, the most frequent mutations are 23403 A > G (D614G, S gene), 241 C > T (5' UTR), 14408 C > T (P4715L, RdRP gene), 3037 C > T (F942F, NSP3), 28881 G > A (R203K, N gene), 28882 G > A (R203R, N gene), 28883 G > C (G204R, N gene), and

Spike protein D614G and RdRp P323L: the SARS-CoV-2 mutations associated with severity of COVID-19.

PMID: 33412760 2020 Genomics & informatics

Result: In ORF8, 28144T>C mutation at the nucleotide level resulted in L84S mutation at the amino acid level.

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