literature

SARS_CoV_2 mutation literature information.

Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.

PMID: 33966351 2021 Transboundary and emerging diseases

Result: Among these 21 SNPs, we also identified two previously reported SNPs, 8,782.C > T and 28,144.T > C (p-value = 4.03 x 10-28 and 9.73 x 10-33), resulting in a synonymous mutation and a missense mutation (Leu 84 Ser) (Tang et al., 2020) (Table 1).

Table: Leu84Ser

Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing Mutations.

PMID: 34281387 2021 mBio

Result: The first major mutation to appear was L84S in ORF8 (present in 8.6% of the genomes) that has defined the A lineage (i.e., clade S in the GISAID classification).

Table: L84S

SARS-CoV-2 mutations: the biological trackway towards viral fitness.

PMID: 33928885 2021 Epidemiology and infection

Introduction: Among the accessory proteins, ORF3a and ORF8 are brought into limelight due to the rapid spread of cluster V (NSP3:F106F, RdRp:P323L, S:D614G and ORF3a:Q57H) and VI (NSP4:S76S and ORF8:L84S).

Introduction: Among the point mutations, L84S is the predominant one and associated with mild disease symptoms among the hospitalised individuals.

Introduction: Cluster I includes 3037C>T;

RT-qPCR Assays for Rapid Detection of the N501Y, 69-70del, K417N, and E484K SARS-CoV-2 Mutations: A Screening Strategy to Identify Variants With Clinical Impact.

PMID: 34123874 2021 Frontiers in cellular and infection microbiology

Discussion: This finding is important because in Mexico, previously, Hernandez-Huerta et al., only identified the D614G mutation in the spike protein and the L84S mutation in the ORF8 gene and Taboada et al., only reported that the lineages circulating in Mexico changed from late February to March from A2 to B1 but both two studies did not found new lineages establishment in this country.

Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades.

PMID: 34147651 2021 Infection, genetics and evolution

Result: 3 of the clades are due to the high recurrent mutations [Nsp6:L37F (Clade 1), Spike:D614G (Clade 3) and Nsp12:P323L (Clade 4)] and one of the clade is due to the moderately recurring mutation [ORF8:L84S (Clade 2)].

Result: Among the moderately recurring mutations, following mutations are found in the hospitalized patients in the following order of fre

Discussion: 2 MR (ORF8:L84S and ORF3a:G251V.

Development of a genotyping platform for SARS-CoV-2 variants using high-resolution melting analysis.

PMID: 34154921 2021 Journal of infection and chemotherapy

Table: L84S

Activation of NF-kappaB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2.

PMID: 34188167 2021 Scientific reports

Introduction: According to the data from the Global Initiative on Sharing All Influenza Data (GISAID; https://www.gisaid.org), four major clades of SARS-CoV-2 have so far been identified and named clade L (prototype virus Wuhan-Hu-1; GenBank accession number NC_045512), clade G (D614G variant of the spike protein), clade V (G251V variant of ORF3a), and clade S (L84S variant of ORF8).

SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence.

PMID: 34203844 2021 Journal of clinical medicine

Result: conducted in China showed no significant differences between two variants (clade I (ORF3a: p.251G > V, or S: p.614D > G (subclade G)); clade II (ORF8: p.84L > S (28,144U > C) and ORF1ab: p.2839S (8782C > U)) regarding disease severity and blood parameters indicative of severity.

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants' interaction with ACE2 to understand the binding affinity and stability.

PMID: 34217923 2021 Virology

Introduction: Later, six major clades (basal, D614G, L84S, L3606F, D448del and G392D) and 14 subclades were identified by analyzing genome variants of SARS-CoV-2 from all over the world.

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.

PMID: 33925854 2021 Microorganisms

Introduction: Based on GISAID classification, the clade L is considered as wild-type (WT) variant, which consists of initial isolates from China (including reference genome) or other countries mainly involved in the first stage of pandemic; the clade S is defined by L84S mutation in NS8; the clade V is defined by G251V mutation in NS3; the clade G is defined by D614G mutation in S-protein (dominant isolate since spring 2020).

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