literature

SARS_CoV_2 mutation literature information.

Role of the Microbiome in the Pathogenesis of COVID-19.

PMID: 35433495 2022 Frontiers in cellular and infection microbiology

Introduction: Earliest samples from the USA appeared to have been derived from China and belonged to basal or L84S clades, while subsequent infected samples associated with European clades, such as D614G/Q57H.

Table: L84S

Reduced levels of convalescent neutralizing antibodies against SARS-CoV-2 B.1+L249S+E484K lineage.

PMID: 34780883 2022 Virus research

Table: L84S

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Result: Haplotype 1 with the mutation at ORF8 L84S was prevalent post-6-month spread (25.34%) but rarely identified post-1-year pandemic (1.19%).

Table: L84S

Comparative mutational analysis of SARS-CoV-2 isolates from Pakistan and structural-functional implications using computational modelling and simulation approaches.

PMID: 34968862 2022 Computers in biology and medicine

Result: Several mutations have been reported in the ORF8 protein, but L84S is a highly recurred mutation observed in 100 countries.

Table: L84S

Figure: (A) Among the Structural proteins, D614G mutation in spike protein was found the most reoccurring mutation in 171Countries while L84S in ORF8 was observed in 100 countries.

Worldwide SARS-CoV-2 haplotype distribution in early pandemic.

PMID: 35171928 2022 PloS one

Table: p.Leu84Ser

Genomic Diversity of SARS-CoV-2 in Algeria and North African Countries: What We Know So Far and What We Expect?

PMID: 35208920 2022 Microorganisms

Abstract: Lower prevalence was noted for GRY (variant S-N501Y) (5.1%), S (variant ORF8-L84S) (3.1%) and GV (variant of the ORF3a coding protein NS3-G251V) (2.0%).

SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines.

PMID: 35273977 2022 Frontiers in medicine

Introduction: In the US, Q57H mutation in the ORF3a region, and S24L and L84S in ORF8 was found to be prevalent, suggesting a positive effect on transmission or virulence.

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8.

PMID: 35343786 2022 mBio

Abstract: A naturally occurring ORF8 L84S variant that was highly associated with mild COVID-19 showed reduced hIL-17RA binding and attenuated inflammatory responses.

Introduction: Interestingly, patients infected with a SARS-CoV-2 variant carrying the Delta382 deletion or the L84S mutation of the open reading frame 8 (ORF8) accessory protein experienced milder inflammatory responses and attenuated disease outcomes, suggesting a crucial role for ORF8 in triggering COVID-19 proinflammatory sequelae.

Introduction: We also demonstrated that the disruption of ORF8 and hIL-17R interaction attenuated its proinflammatory responses and that a variant form of

An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2.

PMID: 35341060 2022 PeerJ

Introduction: The clade S, a subtype of SARS-CoV-2, was identified to possess the mutation L84S in the ORF8 protein sequence.

Antibody escape and global spread of SARS-CoV-2 lineage A.27.

PMID: 35241661 2022 Nature communications

Table: L84S

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