literature

SARS_CoV_2 mutation literature information.

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

PMID: 33907745 2021 bioRxiv

Abstract: The most common sets of spike mutations in this lineage (now designated as B.1.526) are L5F, T95I, D253G, E484K or S477N, D614G, and A701V.

Method: Human plasma samples were assayed for neutralization activity against lentiviruses pseudotyped with SARS-CoV-2 spike containing a 21-amino acid cytoplasmic tail deletion and either D614G or mutations corresponding to lineage B.1.526 (L5F, T95I, D253G, E484K, D614G, and A701V).

Assessment of basic reproduction number (R0), spatial and temporal epidemiological determinants, and genetic characterization of SARS-CoV-2 in Bangladesh.

PMID: 33930563 2021 Infection, genetics and evolution

Result: On the other hand, we found the unique aa substitutions at position 518 (L> > I) and some unusual mutations like L5F, D138, G594S, and S98F in the S protein.

Result: The remaining other sites were located in different regions within the protein, including L5F, D614G, G769V, E516Q, T791I, L518I.

D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect.

PMID: 33946306 2021 Molecules (Basel, Switzerland)

Discussion: It is worth noticing that, for other frequent variants included in the same study, such as L5F and D839Y, infectivity was virtually unchanged.

Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

PMID: 33975397 2021 Journal of Korean medical science

Method: There were 13 nonsynonymous mutations with a total frequency of > 1,000, and three mutations that are of interest, including D614G, A222V, L18F, S477N, N439K, S98F, L5F, A262S, P272L, P681H, D1163Y, E583D, G1167V, Y453F, E484K, and N501Y.

E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

PMID: 34044192 2021 Infection, genetics and evolution

Result: For these residues under adaptive pressure, six are included in known mutation sites of spike protein, including E484K (L5F, S12F, P26S, D138Y, A688V).

Discussion: The analysis of the South African clade V501 V2 found some similar results for FUBAR evaluation, with the detection of adaptive selection at the sites 5 (L5F), 12 (S12F), and 484 (E484K).

Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.

PMID: 34065789 2021 Microorganisms

Result: Furthermore, other potential mutations (L5F, N354S, A520K, Q675H/R, P681H/R, D936Y, and M1229Y) were detected in the current study (Figure 5c) and have been described for increased infectivity of the virus in vivo.

Discussion: Bangladeshi strains exhibited other S protein mutations or variants, as well as combined variants, such as L5F, L18F, N354S, A520K, Q675H/R, P681H/R, L5F + D614G, and

PMID: 34067745 2021 Viruses

Discussion: In addition, this study observed the presence of individual amino acid variants in the SARS-CoV-2 variants B.1.1.7 (S494P), B.1.525 (A67V, Q677H), B.1.526 (L5F, T95I, S477N), and P2 (V1176F) in the earlier samples.

The Spike of Concern-The Novel Variants of SARS-CoV-2.

PMID: 34071984 2021 Viruses

Introduction: Although the B.1.526 NTD harbours with L5F, T95I, and D253G, three mutations which are distinct from B.1.429, the 3D model of B.1.526 spike predicts a similar structural rearrangement of loop N5 (245-264aa) (Figure 6d).

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.

PMID: 34074255 2021 BMC medical genomics

Abstract: About 94% (16/17) of the virus samples showed D614G on spike protein and 56% of these (9/16) showed other various amino acid mutations on this protein, including L5F, V83L, V213A, W258R, Q677H, and N811I.

Abstract: Virus samples from family cluster-2 (n = 3) also belonged to the clade GH and showed other spike protein mutations of L5F alongside the D614G mutation.

Result: The majority of the virus samples (16/17) possessed D614G substitution on spike protein and 56% of these (9/16) showed other amino acid substitutions on thi

Bioinformatics Analysis Unveils Certain Mutations Implicated in Spike Structure Damage and Ligand-Binding Site of Severe Acute Respiratory Syndrome Coronavirus 2.

PMID: 34121839 2021 Bioinformatics and biology insights

Result: Based on 760 whole sequences from Oceania and South America, the most common mutations are found to be G1124V (25 mutations) and D614G (20 mutations), while other different mutations tend to increase, such as S50L (10 mutations), A262T (11 mutations), L5F (5 mutations), D138H (3 mutations), S221L (3 mutations), G485R (3 mutations) (Table 3).

Result: In the sample sequences isolated for this study, some other mutations were found, such as L5F (19 mutations), D138H (18 mutations), E554D (13 mutations), and P631L (10 mutations).

Browser Board

Co-occurred Entities

Filtrator