Abstract: We unveil, for the first time, that high-frequency mutations R346K/S, N439K, G446V, L455F, V483F/A, F486L, F490L/S, Q493L, and S494P might compromise some of mAbs in clinical trials.
Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants.
PMID: 34379531
2021
Journal of clinical microbiology
Table: L455F
Molecular Dynamics Studies on the Structural Characteristics for the Stability Prediction of SARS-CoV-2.
PMID: 34445414
2021
International journal of molecular sciences
Result: We identified five non-synonymous mutations
Discussion: L455F and F456L are located in the RBD region, which interacts with ACE2.
Discussion: KDCA investigated S protein variants of SARS-CoV-2 in Korean patients using RT-PCR analysis and identified five major mutants (D614G, D614A, L455F, F456L, and Q787H) depending on domain region.
Discussion: The other mutants:D614A, L455F, F456L, and Q787H:show more stability than the wild type in some complexes and are more unstable than the wild type in other situations.
Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.
Figure: Eight mutations (Y453F, L455F, F456L, A475V, A475S, T500S, N501Y, and Y505H) were in the RBD and hACE2 interaction region (RBD/hACE2); 10 mutations (V367I, V382L, R408G, N438K, L452Q, S477N, T478K, E484Q, S494P, and A520S) were in the RBD region but no
Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies.
Result: The actual computational data for mutating these four viral protein residues into the SARS-CoV-2 circulating variants (E406D/Q, L455F/S/V, F456L/Y and Y505F/H/W) account for neutral-to-mildly negative effects on the stability of the corresponding S-RBDCoV-2/LY-CoV016 mAb binding interface, with estimated DeltaDeltaG values all below 1 kcal/mol for all alternative amino acids considered.
Result: The same data survey reported by Starr and coworkers led us to identify the following naturally occurring mutations at the SARS-CoV-2 spike protein residues contacting the LY-CoV016 Ab: E406D/Q, T415A/I/N/P/S, PMID: 34720581
2021
Bioinformatics and biology insights
Result: We also analyzed the effect of 27 missense variants of SARS-CoV-2 spike protein (RBD) on the binding interaction of spike protein with ACE2 and observed that L452Q, T478K, L455F, F456L, S459F, A475V, N439K, L452R, T470N, E484D, E484A, E484K, E484Q, F486L, S494P, S494L, N501T,
ViMRT
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of molecular biology
