literature

SARS_CoV_2 mutation literature information.

Comprehensive annotations of the mutational spectra of SARS-CoV-2 spike protein: a fast and accurate pipeline.

PMID: 32954666 2021 Transboundary and emerging diseases

Result: We also found aa substitutions at six positions within the RBD region that are directly involved in binding with ACE-2 receptor (Wang et al., 2020; Yuan et al., 2020) including N439K (Scotland, Romania), L455F (England), A475V (USA, Australia), and F456L, Q493L and N501Y (USA) (Data S2).

Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants.

PMID: 33589648 2021 Communications biology

Result: The L455F mutation localized on the RBM has low frequency but the highest absolute binding free energy changes, while the A411S localized outside the RBM with low positive binding free energy change has the highest frequency.

SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies.

PMID: 33619509 2021 medRxiv

Table: L455F

Pan-India novel coronavirus SARS-CoV-2 genomics and global diversity analysis in spike protein.

PMID: 33758785 2021 Heliyon

Table: L455F

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.

PMID: 33758839 2021 bioRxiv

Introduction: To assess the neutralization breadth of RBD-NP-elicited Abs, we evaluated serum neutralizing activity against a panel of pseudotyped viruses comprising wild-type (D614G) SARS-CoV-2 S and nine single-residue SARS-CoV-2 RBD mutants detected in clinical isolates (G446S, Y453F, L455F, T478I, E484A/K, F486L, S494P, and N501Y) as well as the B.1.1.7 (H69-V70 deletion, Y144 deletion, N501Y, A570D, P681H, T716I,

PMID: 33880470 2021 bioRxiv

Abstract: We unveil, for the first time, that high-frequency mutations R346K/S, N439K, G446V, L455F, V483F/A, E484Q/V/A/G/D, F486L, F490L/V/S, Q493L, and S494P/L might compromise some of mAbs in clinical trials.

Mutations in the SARS-CoV-2 spike protein modulate the virus affinity to the human ACE2 receptor, an in silico analysis.

PMID: 33883984 2021 EXCLI journal

Abstract: On the other hand, several mutants, including the most prevalent N501Y and B.1.1.7 variants, as well as the K444R, L455F, Q493R, and Y505W variants exhibited lower binding free energy as compared to the WT spike.

Result: The other investigated mutants, including the B.1.1.7 (-13.4 kcal/mol), K444R (-13.8 kcal/mol), Result: Thus, our further analysis was focused on the mutants that exhibited similar or lower binding free energy than that found for the N501Y mutant, including the B.1.1.7, K444R, L455F, Q493R, and Y505W variants (see Table 3(Tab.

Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries.

PMID: 34004284 2021 Genomics

Table: L455F

Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern.

PMID: 34149735 2021 Frontiers in immunology

Result: Thus, RBD variants that could disrupt C1D NAbs include L455F, A475V, F486L, as well as E484K, and G485R.

Result: Thus, C1 NAb epitopes are predicted to be sensitive to K417N/T, Y453F, L455F, A475V, F486L, and N501Y variants.

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants' interaction with ACE2 to understand the binding affinity and stability.

PMID: 34217923 2021 Virology

Result: All other 11 mutations (N501I, N501S, N501T, N501Y, Q493L, Q493H, A475V, L455F, G446S and K417R) were predicted to have a neutral effect on the protein function.

Result: However, T when replaced with S at position 500 reduces the binding affinity between RBD and ACE2, whereas the variants L455F and A475V increase their binding affinity.

Result: The point mutations L455F, A475V and T500

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