literature

SARS_CoV_2 mutation literature information.

Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.

PMID: 35101265 2022 Vaccine

Table: L452R

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.

PMID: 35236358 2022 BMC medicine

Table: L452R

Mutations in the receptor-binding domain of human SARS CoV-2 spike protein increases its affinity to bind human ACE-2 receptor.

PMID: 35109768 2022 Journal of biomolecular structure & dynamics

Abstract: Here, we use the crystal structure of the RBD in complex with ACE-2 available in the public domain and analyse the 250 ns molecular dynamics (MD) simulations of wild-type and mutants; K417N, K417T, N440K, N501Y, L452R, T478K, E484K and S494P.

Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients.

PMID: 35113647 2022 Science immunology

Method: The delta variant contained the following spike changes: T19R, G142D, del156-157, R158G, A222V, L452R, T478K, D614G, P681R and D950N.

Post-Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections and Incidence of the Presumptive B.1.427/B.1.429 Variant Among Healthcare Personnel at a Northern California Academic Medical Center.

PMID: 34137815 2022 Clinical infectious diseases

Abstract: Available specimens were tested for L452R, N501Y, and E484K mutations using reverse-transcription polymerase chain reaction.

Abstract: Of 261 available samples from vaccinated and unvaccinated HCP, 103 (39.5%), including 42 PVSCs (36.5%), had the L452R mutation presumptive of B.1.427/B.1.429.

Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.

PMID: 35114110 2022 Cell reports

Abstract: Further, we engineer a potent ACE2-blocking nAb to sustain binding to S RBD with the E484K and L452R substitutions found in multiple SARS-CoV-2 variants.

Introduction: This powerful technique enabled the rapid selection of a discovered SARS-CoV-2 nAb to extend its neutralizing capability to SARS-CoV-2 expressing the E484K and L452R S RBD mutations found in multiple SARS-CoV-2 variants.

Figure: (B) BLI kinetic analysis of N-612-017 affinity-matured subclones against RBD-wild type, RBD-B.1.351, and RBD-L452R.

Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater.

PMID: 35115523 2022 Nature communications

Figure: WNY1 = E484A/F486P/S494P/Q498Y/H519N/F572N, WNY2 = Q493K/S494P/Q498Y/H519N/T572N, WNY3 = K417T/K444T/E484A/F590Y/Q498H, WNY4 = K417T/N439K/K444N/Y449R/L452R/N460K/S477N/Delta484/

Binding of Human ACE2 and RBD of Omicron Enhanced by Unique Interaction Patterns Among SARS-CoV-2 Variants of Concern.

PMID: 35118473 2022 bioRxiv

Conclusion: Our analysis shows that the Omicron variants exhibit unique interaction patterns reminiscing the features of previously dominated Alpha (N501Y) and Delta (L452R and T478K) variants.

Method: In each variant, the Alpha includes N501Y mutation, Delta has L452R and T478K mutations, and Omicron contains 15 mutated amino acids, i.e., G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A,

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.

PMID: 35118474 2022 bioRxiv

Method: D614G spike mutation: D614G; Alpha (B.1.1.7) spike mutations: Delta69-70, Delta144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; Beta (B.1.351) spike mutations: L18F, D80A, D215G, Delta242-244, R246I, K417N, E484K, N501Y, D614G, A701V; Delta (B.1.61

SARS-CoV-2 Variants Associated with Vaccine Breakthrough in the Delaware Valley through Summer 2021.

PMID: 35130727 2022 mBio

Result: Two other closely studied spike substitutions, E484K and L452R, were not notably enriched among vaccine breakthrough cases, and the D253G substitution was modestly depleted.

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