Introduction: However, there have been several mutations reported in SARS-CoV-2 RBD, such as N501Y, L452R, S477N, E484K, A502S, N439K, S494P, T478K, K417N, and K417T.
Introduction: Therefore, in this study, mutant RBDs of SARS-CoV-2 were selected from the RBD mutation tracker website (CovMT); the following variants were selected: N501Y, L452R, S477N, N439K, and E4
Antibody-Mediated Neutralization of Authentic SARS-CoV-2 B.1.617 Variants Harboring L452R and T478K/E484Q.
Discussion: In this study, we observed a reduced sensitivity of variants carrying L452R towards convalescent and vaccine-elicited sera that was further diminished by substitutions at E484 and T478K in S, respectively (Figure 1).
Discussion: The capacity to neutralize the L452R carrying Epsilon lineages was only moderately reduced for casirivimab and imdevimab (Figure 2).
Discussion: The global displacement of Alpha and the dominance of Delta since spring 2021 shifted the focus towards L452R-carrying variants Epsilon and in particular the lineage B.1.617.
Discussion: This was in agreement with another recent study demonstrating a >10-fold resistance of Delta towards imdevimab and further receptor binding motif (RBM) binding antibodies suggesting that both the L452R an
SARS-CoV-2 Delta Variant Pathogenesis and Host Response in Syrian Hamsters.
Introduction: The characteristic mutations reported in the spike gene of the B.1.617 lineage are D111D, L452R, D614G, P618R, and +-E484Q.
Clinical Characterization and Genomic Analysis of Samples from COVID-19 Breakthrough Infections during the Second Wave among the Various States of India.
Result: Common in B.1.617.2 lineage: ORF1ab P4715L; spikeT19R, L452R, T478K, D614G, and P681R; ORF3a S26L; M I82T; ORF7a V82A and T120I; and N D63G, R203M, and D377Y.
Discussion: K417N, E484K, L452R, and E484Q are the mutations k
Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay.
Introduction: The lineages P.2, P.4, and P.5, carrying the concerning amino acid changes S:E484K, S:L452R, and S:E484Q/N501T, respectively, were also initially detected in samples from Brazil.
A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis.
PMID: 34602531
2021
The Journal of toxicological sciences
Abstract: In this assay, we determined L452R and T478K, among which T478K is an identifier of the Delta variant since L452R is seen in other strains (Kappa and Epsilon variants).
Abstract: Our method discriminated between the L452R mutant and wild-type L452.
Abstract: Seven clinical samples containing the Delta variant were successfully identified as L452R/T478K mutants.
Variants of SARS-CoV-2, their effects on infection, transmission and neutralization by vaccine-induced antibodies.
PMID: 34604978
2021
European review for medical and pharmacological sciences
Abstract: S477N, E484K, Q677H, E484Q, L452R, K417T, K417N and N501Y.
Abstract: The variant, B.1.617 circulating in India and many other countries (double variant) having E484Q and L452R mutations, has raised the infection rate and decreased the neutralization capacity of the vaccine-induced antibodies.
Neutralization of SARS-CoV-2 Variants of Concern Harboring Q677H.
Introduction: Given that neutralizing antibodies often target the receptor binding domain (RBD), recent studies on neutralizing antibody escape by VOCs, including the rapidly spreading B.1.1.7 (United Kingdom, Alpha), B.1.351 (South Africa, Beta), B.1.429 (United States), and P1 (P1-501Y-V3, Brazil, Gamma) variants, have focused on mutations in the RBD, including E484K, N501Y, and L452R, which have been shown to decrease the efficacy of mRNA vaccines to VOCs.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Biochemical and biophysical research communications
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