literature

SARS_CoV_2 mutation literature information.

Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.

PMID: 34451453 2021 Pathogens (Basel, Switzerland)

Discussion: Additionally, B.1.1.7 carries the P681H substitution in the furin-cleavage site and multiple VOIs bear the L452R substitution.

The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R.

PMID: 34452062 2021 Vaccines

Discussion:

Discussion: Herein, we report a novel variant carrying the S protein L452R mutation, which emerged from a local B.1.362 lineage.

Discussion: However, with the penetration of the dominant Alpha variant in December 2020, all local lineages started to decline, including the B.1.362 lineage and the B.1.362+L452R variant.

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany.

PMID: 34452356 2021 Viruses

Abstract: Among those, L18F, L452R and N501Y are located in the epitope regions of the N-terminal- (NTD) or receptor binding domain (RBD) and have been suggested to result in immune escape and higher transmissibility.

Result: Among those, three alterations are of particular concern as they are located in the NTD or RBD epitope regions, respectively, and are suspected to result in immune escape (L18F, L452R and N501Y) and/or higher infectivity and transmissibility (L452R and N501Y).

Result: Antibody escape data for the RBD, int

Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM Refiner.

PMID: 34452511 2021 Viruses

Result: T478K and L452R each have lineage associations.

Result: Sequences from the RBD amplicon matched reference sequence, lineages B.1.1.7 with '1501T(N501Y) 1709A(A570D)', P.1 with '1250C(K417T) 1450A(E484K) 1501T(N501Y)', or had the single variations of T478K or L452R (Supplementary 11).

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

PMID: 34462752 2021 bioRxiv

Method: Individual point mutations for Alpha (NSP3: P153L, T183I, A890D, I1412T; NSP6: SGF106-108del; NSP12: P323L; Spike: HV69-70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H; ORF8: Q27stop, R52I, Y73C, S84L<

Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein.

PMID: 34463219 2021 Journal of biomolecular structure & dynamics

Method: Using the same PDB ID, the SARS-CoV-2 variants (N501Y, E484K, K417N/T, A475V, L452R,

Result: Li and co-workers identified single amino acid substitutions in the viral spike RBD (A475V, I472V, L452R, V483A, and F490L) which were found to affect binding of neutralizing antibodies (Li et al.,) and were identified to occur in higher frequencies during the time evolution of SARS-CoV-2 spike protein RBD indicating stronger transmission capacity (Chen et al.,).

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: L452R

Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect.

PMID: 34472141 2021 Phytotherapy research

Result

Result: As shown in Figure 4, sequence alignment revealed that these sequences are highly homologous, and mutations N501Y, E484Q, and L452R were highlighted in red.

Result: Importantly, the highlighted mutated residues N501Y of B.1.1.7, and E484Q and L452R of B.1.617 were also in green, indicating that the built models are reliable.

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.

PMID: 34478710 2021 The Journal of biological chemistry

Result: S1), notably mutations L452R (8.8%), E484K (7.7%), T478K (5.9%), S477N (2.2%), and N439K (1.2%), which are also found in other various VOCs and were shown to either increase infectivity or promote the evasion of antibody responses.

Discussion: The majority of them bound better to ACE2 at physiological temperature, notably for lineages harboring the N501Y mutation (B.1.1.7, B.1.351, and P.1) or the L452R mutation (B.1.617.2 and B.1.429).

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.

PMID: 34484190 2021 Frontiers in immunology

Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,

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