Abstract: We constructed nanobody tandems and identified nanobody monomers that tolerate the K417N/T, E484K, N501Y, and L452R immune-escape mutations found in the Alpha, Beta, Gamma, Epsilon, Iota, and Delta/Kappa lineages.
Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences.
PMID: 34303698
2021
The American journal of pathology
Result: These two variants are characterized by a core group of amino acid replacements in spike protein: L452R, T478K or E484Q, D614G, and P681R (Figure 6).
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.
Discussion: These strains have substitutions in the RBD (L452R and E484K/Q) and elsewhere in the spike that might confer some degree of neutralization resistance in our in vitro assays.
The challenge of screening SARS-CoV-2 variants of concern with RT-qPCR: One variant can hide another.
PMID: 34332998
2021
Journal of virological methods
Abst
Result: Of these 47 had the L452R mutation.
Result: This shows an increase in the number of variants carrying the L452R mutation between weeks 22 and 25.
Discussion: Next, we select samples for which no mutation has been detected (to flush out L452R and W152C mutations), as well as samples with an isolated E484K mutation.
Discussion: Since early May 2021, a new NovaplexSARS-CoV-2 Variants II Assay has been available on the market to detect L452R, K417N, K417T and W152C mutations.
Discussion: The other two targets of the Variant II Assay are the L452R and W152C mutations.
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Abstract: The increased rigidity of the amino acid sequence YRYRLFR from the SSSCPreds data of B.1.427/429 near the L452R mutation site contributes to the 2-fold increased B.1.427/B.1.429 viral shedding in vivo and the increase in transmissibility relative to wild-type circulating strains in a similar manner to D614G.
Result: The L452R mutation increases the rigidity of the amino acid sequence YRYRLFR.
Result: The SSSCPreds data of B.1.427/429 and B.1.617.2 near the L452R mutation site are larg
Result: The increased rigidity from the SSSCPreds data of L452R mutation seems to rationalize well the 2-fold increased B.1.427/B.1.429 viral shedding in vivo and the 18.6-24% increase in transmissibility relative to wild-type circulating strains in a similar manner to D614G.
Differential Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern.
Introduction: Even though both Epsilon and Kappa/Delta variants share L452R mutation, Kappa and Delta variants show similar trends in force profiles to WT from D = 55 A to 75 A (Figure 1A).
Introduction: In addition, Epsilon variant is likely to be relatively easily dissociated from ACE2 than others due to its destabilized RBD structure upon the L452R mutation.
Introduction: It should be noted that this difference between Kappa/Delta and Epsilon might stem from the limitation in our model in this study, as we only employed L452R mutation in RBD for Epsilon variant without D614G mutation.
Introduction: Newly reported Kappa and Delta variants display the same L452R mutation as Epsilon, but each variant contains an additional mutat
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.
Result: For example, the Indian variant B.1.617.2 (also known as Delta), contains a core number of mutations in Spike (G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H) but also additional sub-strain variations (T95I, H1101D or V382L).
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.
Introduction: L452R and N439K are associated with a modest reduction in antibody-dependent neutralization by immune sera, whilst variants containing E484K display a reduction th
Result: However, we observed a reduction in neutralization in some sera against N439K mutant (0.53+-0.45) as reported in, which was not observed when Delta69-70 was added (Figs 2H and S5), and also against L452R mutant (0.48+-0.23) that is associated with the most recent variants of concern B.1.427/9, as reported in.
Result: Interestingly, N501Y, L452R and S417N have been associated with increased viral transmission and, when combined with E484K, augmented resistance to neutralizing antibodies.
Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Proc Natl Acad Sci U S A
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