Differential Interactions between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern.
PMID: 34856802
2021
Journal of chemical theory and computation
Abstract: Among all variants investigated in this work, RBD of the Epsilon (L452R) variant is relatively easily detached from ACE2.
Abstract: We report that RBD of the Alpha (
Method: From the WT RBD structure, each variant was modeled with the following mutations: Alpha (N501Y), Beta (K417N, E484K, N501Y), Gamma (K417T, E484K, N501Y), Epsilon (L452R), Kappa (L452R, E484Q), and Delta (L452R, T478K).
Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine.
Discussion: Here we show using a RBD containing the mutations T478K and L452R present in the Delta variant that volunteers vaccinated with CoronaVac exhibit reduced blocking antibodies compared to the WT RBD but we report a seropositivity of 78.57% and 55.76% by sVNT and cVNT ( Tables 1 and 2 ), respectively, which suggests that the vaccine confers protection against this variant.
Discussion: Pseudoviruses carrying the L452R mutation display higher infectivity in cell culture and when incubated with sera from subjects vaccinated with Moderna mRNA-1273 or BNT16b2, as compared to the WT strain.
Discussion: The Delta variant (first identified in India) exhibit the RBD mutations T478K, L452R and
Evolutionary and Antigenic Profiling of the Tendentious D614G Mutation of SARS-CoV-2 in Gujarat, India.
Abstract: The D614G variant in spike protein is reported to have a very high frequency of >95% globally followed by the L452R and P681R, thus getting significant attention.
Discussion: In addition, it is concurrently seen with other mutations like P681R, L452R, T19R, E156G, T478K.
Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan.
PMID: 34869681
2021
Frontiers in cardiovascular medicine
Abstract: SARS-CoV-2 variants of concern/interest (VOC/VOI) carrying the spike protein mutants E484K, N501Y, or L452R were identified by PCR-based analysis.
Method: As the proportion of SARS-CoV-2 variants carrying either N501Y, E484K, and L452R mutations was expanded, RT-PCR was performed using VirSNiP SARS-CoV-2 (TIB Molbiol, Berlin, Germany).
Figure: Based on the results of the epidemiologic analysis in Tokyo, the variant carrying E484K alone, N501Y alone, and L452R alone were considered as R.1 lineage variant, alpha variant, and delta variant, respectively.
Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America.
PMID: 34873910
2021
The journal of physical chemistry letters
3Introduction: Moreover, we have pointed out that Y449S and Y449H are two vaccine-resistant mutations, and ""Y449S, S494P, K417N,
Introduction: Later, we provided a list of most likely vaccine escape RBD mutations with high frequency, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.
Analysis of the ARTIC Version 3 and Version 4 SARS-CoV-2 Primers and Their Impact on the Detection of the G142D Amino Acid Substitution in the Spike Protein.
Introduction: Indeed, when we examine 12,441 samples from Houston Methodist patients collected since April of 2021, comparing the occurrence of G142D with L452R (another hallmark Delta substitution in spike), it becomes clear that the G142D uptick is an artifact that corresponds precisely with our adoption of the V4 primers in mid-July 2021.
Figure: (E) Frequency of L452R (gray), D950N (blue), and G142D (orange) amino acid substitutions observed in SARS-CoV-2-positive samples from April through August of 2021.
Figure: L452R, D950N, and G142D are hallmark amino acid substitutions of the Delta variant.
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.
Introduction: All three of the genomes carrying the L452R/N501Y combination belonged to the A.27 lineage (clade 19B) and did not encode the D614G mutation that predominates most global infections today.
Introduction: In addition to strains carrying L452R individually, variant strains carrying a combination of L452R + N501Y (3/117, 2.6%) were also identified.
Introduction: In addition to the L452R + N501Y double mutant, a single genome was identified that carried a unique combination of E484K + N501T spike RBD mutations in a B.1 lineage genome (clade 20C
Additional Positive Electric Residues in the Crucial Spike Glycoprotein S Regions of the New SARS-CoV-2 Variants.
Emergence of Novel SARS-CoV-2 variants in India: second wave.
PMID: 34898481
2021
Journal of infection in developing countries
Abstract: The remaining sequences were assigned to clade 20H, 20J, 20D, 20C, 20G,20E,19A and 19B.The spike mutation frequencies of L452R, E484Q and P681R in Indian state of Maharashtra were 62.4%, 66.5% and 61.5% respectively.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Nature communications
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