literature

SARS_CoV_2 mutation literature information.

Gasless laparoendoscopic single-site surgery for management of unruptured tubal pregnancy in a woman with moderate COVID-19 pneumonia after administration of remdesivir and casirivimab-imdevimab: A case report.

PMID: 34786352 2022 Case reports in women's health

Abstract: Real-time reverse transcription-polymerase chain reaction assay detected SARS-CoV-2, which was subsequently identified to be an L452R variant.

Conclusion: Real-time reverse transcription polymerase chain reaction assay (RT-PCR) was positive for SARS-CoV-2, which was subsequently shown to be an L452R variant.

Structural and functional insights into the major mutations of SARS-CoV-2 Spike RBD and its interaction with human ACE2 receptor.

PMID: 34955621 2022 Journal of King Saud University. Science

Introduction: In India's second COVID-19 wave, the newest significant variants, Delta and Kappa, were discovered to share two mutations: E484Q and L452R.

Introduction: In the present studies, we have modelled the mutant structures of Spike protein-L452R, T478K and N501Y through in silico mutagenesis technique and evaluated their binding interactions with human ACE2 with respect to the native spike protein using protein-protein docking method.

Method: The interaction of ACE2 with the three mutant models of Spike (L452R, T478K and N501Y) were studied using High

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants.

PMID: 34921776 2022 Cell host & microbe

Result: For example, Beta-44, sensitive to L452R/T478K mutations, is perched adjacent to residue 478, while mAbs, Beta-20, -22, and -29 suggested to recognize an epitope related to residue 417 are tightly clustered atop this residue.

Result: MAb Beta-26 requires the Beta E484K mutation for potent neutralization but is also exquisitely sensitive to the L452R/T478K mutations found in Delta.

Result: We performed live virus neutralization assays using the following viruses, containing the indicated changes in the RBD: Victoria (an early Wuhan related strain), Alpha (N501Y), Beta (K417N, E484K, and N501Y), Gamma (

PMID: 34915409 2022 International immunopharmacology

Introduction: N439K, L452R, and Y453F showed an increase in ACE2 receptor binding ability.

Introduction: Currently, there are four variants of concerns: Alpha variant (B.1.1.7; RBD mutations: N501Y, A570D), Beta (B.1.351; RBD mutations: K417N, E484K, and N501Y), Gamma (P.1, B.1.1.28.1; RBD mutations: K417N/T, E484K, and N501Y) and Delta (B.1.617.2; RBD mutations: L452R, T478K).

Efficacy of mRNA, adenoviral vector, and perfusion protein COVID-19 vaccines.

PMID: 34906769 2022 Biomedicine & pharmacotherapy

Introduction: Consequently, ten mutations in the spike protein of B.1.617.2 strain, including T19R, (G142D*), 156/157del, R158G, L452R, T478K, D614G, P681R, and D950N were identified.

Table: L452R

Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.

PMID: 34801754 2022 Infection, genetics and evolution

Result: 5D) share the same set of mutations on the spike protein (S13I,

Figure: L18F, E484K, N501Y, D614G, H655Y, and V1176F are associated with the Gamma variant of concern, and S13I, W152C, L452R are associated with the Epsilon variant of concern.

Figure: The substitution L452R is observed in the Epsilon variant of concern.

Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India.

PMID: 34896696 2022 Journal of infection and public health

Introduction: Along with the clade specific mutations, these variants have their own sets of characteristics mutations including several mutations in the S glycoprotein like Delta69-70, Delta144-145, N501Y, A570D, P681H, T716I, S982A, D1118H in the Alpha variant; D80A, D215G, Delta241-243, K417N, E484K, N501Y, A701V in the Beta variant; L18F, T20N, P26S, D138Y, R190S,

A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.

PMID: 34896524 2022 Gene

Introduction: While most of alterations in the receptor binding domain (RBD) reduce infectivity, A475V, L452R, V483A, and F490L variants induce resistance to some neutralizing antibodies.

Table: L452R

Discussion: L452R, T478K, N501Y and S477N have been the most frequently detected mutations in RDB.

In vitro data suggest that Indian delta variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion.

PMID: 34453338 2022 Allergy

Result: Anti-RBD IgG ELISA shows that antibodies induced by infection with wild-type Wuhan SARS-CoV-2 fail to recognize the RBD mutants L452R/E484Q (variant B.1.617) and E484K (variants P.1 and B.1.351), while recognition of RBDN440K is unaltered.

Result: Binding kinetics of RBD mutants to ACE2 show increased affinity due L452R/E484Q and E484K mutations.

Result: In contrast to direct binding of immune sera to RBD, inhibition of the RBD-ACE2 interaction was more severely affected and reduced for all mutations, most notably E484K<

Reduced sensitivity of the SARS-CoV-2 Lambda variant to monoclonal antibodies and neutralizing antibodies induced by infection and vaccination.

PMID: 34818119 2022 Emerging microbes & infections

Introduction: The L452R mutation found in the Delta, Kappa, and Epsilon variants has been reported to enhance viral infectivity and fusogenicity while promoting viral replication.

Discussion: In addition, our previous studies revealed that escape of the L452R and E484 K mutants from mAbs frequently occurred in conjunction.

Discussion: Our previous study found that the L452R and F490L mutations can cause escape from mAb X593, consistent with the results of the L452Q and F490S mutations in the present study.

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