Conclusion: More specifically, we found that mutations N501Y, E484K, and K417N in the United Kingdom (UK), South Africa, or Brazil variants, L452R and E484Q in the India, as well as mutations N439K, S477N, S477R, and N501T are all associated with the enhancement of the BFE of the S protein and ACE2, confirming the earlier speculation.
Conclusion: Note that L452R in the California variant B.1.427 is as infectious as N501Y and as disruptive as E484K.
Conclusion: We report that rapidly growing mutations
Novel SARS-CoV-2 variants: the pandemics within the pandemic.
PMID: 34015535
2021
Clinical microbiology and infection
3Introduction: Search terms used in various combinations were as follows: ""SARS-CoV-2"", ""variants"", ""variants of concern"", ""VOC"", ""variants of interest"", ""VOI"", ""mutations"", ""evolution"", ""B.1.1.7"", ""B.1.351"", ""P.1"", ""B.1.148"", ""B.1.1.28"", ""N501Y"", ""E484K"", and ""L452R""."
Method: HMN.19B - Henri Mondor 19B variant identified in France: Very little information is available about this variant, but it contains the L452R and N501Y mutations, both of which have been linked to increases in transmissibility.
Method: Immune escape concerns: Both the E484Q and L452R
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Introduction: In the receptor-binding site (RBS) of the spike (S) protein receptor-binding domain (RBD), the B.1.1.7 lineage has acquired an N501Y mutation, B.1.351 and P.1 lineages share this mutation along with K417N/T and E484K, whereas the California variants have an L452R mutation that is also present in the Indian variant B.1.617 with E484Q.
Multiplex SARS-CoV-2 Genotyping Reverse Transcriptase PCR for Population-Level Variant Screening and Epidemiologic Surveillance.
PMID: 34037430
2021
Journal of clinical microbiology
Abstract: The assay revealed the rapid emergence of the L452R variant in our population, with a prevalence of 24.8% in December 2020 that increased to 62.5% in March 2021.
Abstract: We designed and analytically validated a one-step multiplex allele-specific reverse transcriptase PCR (RT-qPCR) to detect three nonsynonymous spike protein mutations (L452R, E484K, N501Y).
Abstract: We detected 1,567 L452R mutations (38.7%), 34 N501Y mutations (0.84%), 22 E484K mutations (0.54%), and 3 (0.07%) E484K plus N501Y mutations.
An Epidemiological Analysis of SARS-CoV-2 Genomic Sequences from Different Regions of India.
Discussion: Recently, a new PangoLIN lineage (B.1.617) was identified in Indian SARS-CoV-2 sequences, with the E484Q and L452R mutation (commonly known as a double mutant) in the spike protein of SARS-CoV-2, which is considered to have higher transmission rates.
The Spike of Concern-The Novel Variants of SARS-CoV-2.
Introduction: Antibodies and sera from vaccinated people are, however, able to neutralise a pseudotyped VSV virus carrying the B.1.617 spike with the mutations R21T, E154K, Q218H, L452R, E484Q, D614G, P681R, and H1101D (GISAID Accession ID: PI_ISL_1360382).
Introduction: B.1.617 is currently not a defined variant, as it consolidates a group of sequence clusters within clade G that share the common signature mutations: G142D, L452R, E484Q, D614G, and P681R (Table 1) as well the silent mutation
Figure: Three circulating human variants in the JS7 sequence, L452R (recent California), E484K and N501Y are indicated by red arrows, yellow side chains in the structure above.
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
PMID: 34103090
2021
European journal of medical research
Table: L452R
SARS-CoV-2 reinfection with a virus harboring mutation in the Spike and the Nucleocapsid proteins in Panama.
PMID: 34107326
2021
International journal of infectious diseases
Result:
Result: In contrast, the L452R mutation is located in the region binding domain (RBD) for ACE2 receptor, D614G being between the RBD and the amino acid bridge between the S1 and S2 subunits.
Discussion: Spike mutation L452R, decreasing sensitivity to neutralizing antibodies, has been associated with immune escape and reinfection and is present in the variant of interest (VOI) B.1.526.1, and the variants of concern (VOC) B.1.427 and B.1.429.
Discussion: SARS-CoV-2 genome analysis showed that both infections were induced by viruses from Panamanian endemic lineages, A.2.4 for the first, and A.2.5, containing Spike mutations D614G and L452R, for the second.
Targeting SARS-CoV-2 Receptor Binding Domain with Stapled Peptides: An In Silico Study.
PMID: 34114829
2021
The journal of physical chemistry. B
Method: Examples of such mutations are Asn439Lys (N439K) and Leu452Arg (L452R).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Genomics
Browser Board
Co-occurred Entities
Filtrator
ViMRT