Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India.
Abstract: Delta variant spike mutation of T19R, G142D, E156G, L452R, and deletion (F157 and R158) helps in escaping antibody response, T478K and D614G enhance viral affinity with ACE2 receptor while P681R and D950N result in higher replication and transmissibility by cleaving S1/S2 at furin site.
Abstract: Similarly, the L452R mutation of B.1.617.2 (Delta) variant is present in A.2.5.
Introduction: Another variant, A.2.5, likely spread north from Central America to the Quebec province in Canada and accumulated deletions 141-143 at the NTD and the L452R mutations in RBD.
Introduction: Further analysis revealed the convergent acquisition of the D614G and L452R signature mutations of the B lineages and Delta variant, respectively, and a mutational jump of 23 mutations, a characteristic of most of the VOCs.
Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.
Introduction: The most recent variants, referred to as the Kappa and the Delta variants, are characterized by six mutations (E154K, L452R, E484Q, D614G, P681R, and Q1071H), and eight mutations (T19R, del156/157, R158G, L452R, T478K, P618R, D614G, and D950N) on the spike gene, respectively.
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.
High throughput sequencing based direct detection of SARS-CoV-2 fragments in wastewater of Pune, West India.
PMID: 34688738
2022
The Science of the total environment
Conclusion: The observation of mutations L452R and E484Q associated with B.1.617.1 variant lineage in similar period of declaration as variant of concern provides a conclusive evidence of WBE as early warning system.
Result: Notably, nine mutations in the Spike region (S: L452R, S:C480R, S: E484Q, S: D614G, S: P681R, S: N801, S: D950N, S:
Table: L452R
An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.
Introduction: These variants are characterized by the S: L452R, which could affect neutralization by monoclonal antibodies.
Result: Other lineages with L452R included A.2.5, B.1.526.1, and B.1.1.487 (Supplementary Figure 2).
Result: Others, such as S:P681H, S:L452R, N:R203K, and S:E484K, were present in multiple lineages and showed an undulating pattern (Supplementary Table 2).
Result: This lineage, similar to B.1.429, harbors the S: L452R.
Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents.
Result: The Delta variant carries only L452R and T478K mutations in its RBD region, while the Omicron carries as much as fifteen RBD mutations of G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H.
Genetic variations from successive whole genome sequencing during COVID-19 treatment in five individuals.
PMID: 35035981
2022
New microbes and new infections
Table: L452R
Aggregation of high-frequency RBD mutations of SARS-CoV-2 with three VOCs did not cause significant antigenic drift.
Introduction: As of March 2021, the 15 most commonly observed mutations in the RBD were as follows: V367F, P384L, K417N, N439K, L452R, Y453F, S477N, S477R, T478K, E484K, S494P, N501T, N501Y, A520S, and A522S, which were located at 13 sites in the RBD.
Introduction: Mutations such as N501Y, S477N, PMID: 35026305
2022
Journal of virological methods
Introduction: The most recent VOC B.1.617.2 contains L452R and P681R mutations.
Discussion: However, new important variants such as B.1.617.1 (kappa), B.1.617.2 (delta) and B.1.617.3 have subsequently emerged, with mutations such as L452R and P681R that are not detected by these assays, necessitating additional panels.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Microbial pathogenesis
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