Abstract: Concurrent with the upsurge of the second wave in March 2021, 73% (33/45) of RBD sequences harboured L452R/E484Q mutations characteristic of the Kappa variant.
Abstract: In April 2021, co-circulation of Kappa (37%) and Delta (L452R/T478K, 59%) variants was recorded.
Result: All six Indian variants of the B.1.617.1
Discussion: Interestingly, the L452R mutation was maintained.
Discussion: Regarding the L452R and E484Q mutations in the Kappa variant, the substitution of a hydrophobic leucine (L) with a hydrophilic arginine (R) is similar to what occurred in the California variant, which was shown to correlate with increased transmissibility and decreased antibody neutralization.
Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California.
Abstract: Vaccine breakthrough infections were more commonly associated with circulating antibody-resistant variants carrying >=1 mutation associated with decreased antibody neutralization (L452R/Q, E484K/Q and/or F490S) than infections in unvaccinated individuals (78% versus 48%, P = 1.96 x 10-8).
Modeling SARS-CoV-2 spike/ACE2 protein-protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related human protein targets, for COVID-19 handling in the 3PM context.
Abstract: By using our pipeline, we built 3D comparative models of the SARS-CoV-2 spike RBD/ACE2 protein complexes for the VoC B.1.1.7-United Kingdom (carrying the mutations of concern/interest N501Y, S494P, E484K at the RBD), P.1-Japan/Brazil (RBD mutations: K417T, E484K, N501Y), B.1.351-South Africa (RBD mutations: K417N, E484K, N501Y), B.1.427/B.1.429-California (RBD mutations: L452R), the B.1.141 (
SARS-CoV-2 multiplex RT-PCR to detect variants of concern (VOCs) in Malaysia, between January to May 2021.
PMID: 35026305
2022
Journal of virological methods
Introduction: The most recent VOC B.1.617.2 contains L452R and P681R mutations.
Discussion: However, new important variants such as B.1.617.1 (kappa), B.1.617.2 (delta) and B.1.617.3 have subsequently emerged, with mutations such as L452R and P681R that are not detected by these assays, necessitating additional panels.
Aggregation of high-frequency RBD mutations of SARS-CoV-2 with three VOCs did not cause significant antigenic drift.
Introduction: As of March 2021, the 15 most commonly observed mutations in the RBD were as follows: V367F, P384L, K417N, N439K, L452R, Y453F, S477N, S477R, T478K, E484K, S494P, N501T, N501Y, A520S, and A522S, which were located at 13 sites in the RBD.
Introduction: Mutations such as N501Y, S477N, PMID: 35035981
2022
New microbes and new infections
Table: L452R
Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents.
Result: The Delta variant carries only L452R and T478K mutations in its RBD region, while the Omicron carries as much as fifteen RBD mutations of G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H.
An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.
Introduction: These variants are characterized by the S: L452R, which could affect neutralization by monoclonal antibodies.
Result: Other lineages with L452R included A.2.5, B.1.526.1, and B.1.1.487 (Supplementary Figure 2).
Result: Others, such as S:P681H, S:L452R, N:R203K, and S:E484K, were present in multiple lineages and showed an undulating pattern (Supplementary Table 2).
Result: This lineage, similar to B.1.429, harbors the S: L452R.
Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory Approach.
Introduction: The most recent variants, referred to as the Kappa and the Delta variants, are characterized by six mutations (E154K, L452R, E484Q, D614G, P681R, and Q1071H), and eight mutations (T19R, del156/157, R158G, L452R, T478K, P618R, D614G, and D950N) on the spike gene, respectively.
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.
SARS_CoV_2 mutation literature information.
PMID: 
2022
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