Result: All strains within this B.2/B.6 lineage shared genetic variation G11083T, encoded for amino acid changes from leucine to phenylalanine at position 37 of nsp6 in ORF1ab.
Table: L37F
SARS-CoV-2 genetic variations associated with COVID-19 pathogenicity.
Result: All SARS-CoV-2 strains belonged to clade 19A identified by Nextstrain, and they harbored a single nucleotide mutation at position 11083 (G11083T transversion), leading to a nonsynonymous amino acid substitution (Leu37Phe) in nonstructural protein 6 (nsp6), as previously described from the Diamond Princess outbreak event.
Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection After Recovery from Mild Coronavirus Disease 2019.
1Abstract: The spike protein D614G substitution that defines the clade ""G"" emerged in reinfection, while mutations that characterize the clade ""V"" (ie, nsp6 L37F and ORF3a G251V) were present at initial infection."
5Result: Of these, nsp6 L37F and ORF3a G251V were the key substitutions that characterized clade ""V""."
Result: Interestingly, the mutation of L37F caused stiffness in the secondary structure of Nsp6 and leads to low stability of the protein structure as observed in most recent strains isolated from Asia, America, Oceania, and Europe.
Result: Mutation L37F (Nsp6) and T85I (Nsp2) were also highly conserved and thus could profoundly damage the function of the respective protein.
Result: Out of 14 high-frequency SNPs, only 9 mutations (Nsp2 [T85I], Nsp3 [S1103P], Nsp6 [L37F], Nsp12 [P324L
The extent of molecular variation in novel SARS-CoV-2 after the six-month global spread.
PMID: 33677109
2021
Infection, genetics and evolution
Abstract: Phylogenetic tree analysis with Neighbor-Joining and Maximum-Parsimony methods indicated that the haplotypes of SARS-CoV-2 genome sequences were classified into four clades with the unique nucleotide and amino acid changes: T27879C (ORF8 L84S) in clade 1 (25.34%), A23138G (spike D614G) in clade 2 (63.54%), G10818T (nsp6 L37F), C14540T (nsp12 T442I), and G25879T (ORF3a V251F) in clade 3 (2.58%), and miscellaneous changes in
Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccines.
Abstract: In majority (above 10%) of virus population, the most frequent and common mutation points between global excluding India and India are L37F, P323L, F506L, S507G, D614G and Q57H in NSP6, RdRp, Exon, Spike and ORF3a respectively.
Table: L37F
Discussion: In addition to these mutation points, the most frequent (in more than 10% of virus population) and common mutation points between global excluding India and India are G11083T (L37F), T19557A
SARS-CoV-2 Genome from the Khyber Pakhtunkhwa Province of Pakistan.
Result: A substitution of aliphatic Leu with an aromatic Phe amino acid might have functional implications, where the Phe residue performs cation-pi interactions, affecting protein interactions in the L37F MT.
Result: In the current study, NSP6 harbors two mutations:L37F (5 isolates) and M86I (2 isolates).
Result: Mutation L37F in NSP6 leads to a weak SARS-CoV-2 subtype which may help in SARS-CoV-2 transmission and evolution across various regions over time during the pandemic.
Result: Mutation L37F is present outside the trans-membrane and as a part coil segment.
Result: Mutations (L3606F) (Table 2), which link with the position
SARS_CoV_2 mutation literature information.
PMID: 
2021
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