Result: Clades are characterized as S (C8782T, T28144C, NS8-L84S), L (C241, C3037, A23403, C8782, G11083, G25563, G26144, T28144, G228882), V (NSP6-L37F, NS3-G251V), G (S-D614S), GH (S-D614S, NS3-Q57H), S (S-D614S, NG204R).
Result: Other key variants including ORF3a: Q57H, ORF1ab: T265I (NSP3: PMID: 33875719
2021
Scientific reports
Introduction: Such changes include: L84S in NS8 for clade S; coexisting L37F and G251V mutations in NSP6 and NS3, respectively for clade V; D614G mutation in the spike protein (S) for clade G.
Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity.
Discussion: Clade V is hallmarked by 2 nonsynonymous variants, 11083G>T (L37F ORF1ab) and 26144G>T (G251V ORF3a), leading to alterations in the NSP6 and NS3 proteins, respectively.
Impact of meteorological parameters and population density on variants of SARS-CoV-2 and outcome of COVID-19 pandemic in Japan.
Result: Among 22 point mutations at N and other eight non-structural proteins, eight namely, N_S194L, N_R203K, N_G204R, NS3_Q57H, NSP2_T85I, NSP5_G15S, NSP6_L37F and NSP12_P323L were persistent throughout the COVID-19 pandemic in Japan.
Table: L37F
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.
Result: Fifteen variants with the prevalence >5% were identified, including (i) four variants in nucleocapsid: S194L (6.29%), R203K (28.45%), G204R (28.13%), and A220V (25.96%); (ii) four variants in spike: L18F (12.08%), A222V (26.14%), S477N (6.62%), and D614G (93.88%); (iii) two variants in NSP2: T85I (15.38%) and I120F (5.23%); (iv) five variants in each of the 5 proteins: L37F (6.52%) in NSP6, P323L (93.74%) in
The Novel Coronavirus Enigma: Phylogeny and Analyses of Coevolving Mutations Among the SARS-CoV-2 Viruses Circulating in India.
PMID: 33496683
2020
JMIR bioinformatics and biotechnology
5Result: The other 21 (22.1%) samples, which represent the ""minor group,"" harbored 5 coexisting mutations: 23929C>T (Y789Y) in the S gene, 28311C>T (P13L) in the N gene, 6312C>A (T1198K) in the NSP3 gene, 11083G>T (L37F) in the NSP6 gene, and 13730C>T (A97V) in the
Abstract: All the minor group mutations, except 11083G>T (L37F, NSP6 gene), were unique to the Indian isolates.
Identification of the nucleotide substitutions in 62 SARS-CoV-2 sequences from Turkey.
Discussion: G11083T, corresponding to the amino acid substitution L37F within Nsp6 protein, was present in 38% of the samples (24/62) and this mutation was previously seen in SARS-CoV-2 sequences analyzed from all over the world (Benvenuto et al., 2020; Wang et al., 2020).
Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam.
Decoding Asymptomatic COVID-19 Infection and Transmission.
PMID: 33179934
2020
The journal of physical chemistry letters
Abstract: Artificial intelligence, sequence alignment, and network analysis are applied to show that NSP6 mutation L37F may have compromised the virus's ability to undermine the innate cellular defense against viral infection via autophagy regulation.
Abstract: On the basis of the genotyping of 75775 SARS-CoV-2 genome isolates, we reveal that asymptomatic infection is linked to SARS-CoV-2 11083G>T mutation (i.e., L37F at nonstructure protein 6 (NSP6)).
Introduction: A piece of recent news reported that half of the COVID-19 cases in Singapore are symptomless, which matches our finding that mutation 11083G>T-(L37F) is relevant to asymptomatic infections.|mgd
Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR(-/-) mice.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Heliyon
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