Coronavirus Genomes and Unique Mutations in Structural and Non-Structural Proteins in Pakistani SARS-CoV-2 Delta Variants during the Fourth Wave of the Pandemic.
Introduction: Similarly, another mutation was reported in the NSP6 at the nucleotide position, 11083, G>T mutation, which results in the mutation L37F.
Table: L37F
Rapid SARS-CoV-2 Intra-Host and Within-Household Emergence of Novel Haplotypes.
Result: G11083T (NSP6:L37F), on the other hand, has been hypothesized to prevent the fusion of the autophagosomes to the cell lysosomes, affecting viral replication and evasion from cellular immunity.
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1.
PMID: 34997207
2022
Cell death and differentiation
Abstract: L37F NSP6 variant, which was associated with asymptomatic COVID-19, exhibited reduced binding to ATP6AP1 and weakened ability to impair lysosome acidification to induce pyroptosis.
Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh.
Result: Moreover, several mutations were found that persisted, (I120F, T412I, L37F, P323L, G204R, R203K, and D614G) for more than 6 weeks (Table 1 and.