Method: pS-B.1.1.7 and pS-B.1.351 plasmids were constructed with mutant S genes expressing the spike protein of the B.1.1.7 variant (GenBank: QQH18545.1, containing the H69, V70, and Y145 deletions and N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H mutations) and B.1.351 variant (GenBank: QRI43207.1, containing the L242, A243, and L244 deletions and L18F, D80A, D215G, S305T, K417N, E484K, N501Y, D614G
Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.
Introduction: The Beta (B.1.351) variant encodes an S protein with nine mutations (L18F, D80A, D215G, Del 241-243, K417N, E484K, N501Y, D614G and A701V, three of which (K417N, E484K and N501Y) are in the RBD.
Introduction: The Gamma P.1 variant encodes an S protein with 12 mutations (L18F, T20N, P26S, D138Y, R190S, PMID: 34931200
2021
medRxiv
Introduction: The Beta variant contained spike mutations L18F, D80A, D215G, Delta242-244, R246I, K417N, E484K, N501Y and A701V.
The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.
PMID: 34940505
2021
Journal of developmental biology
Introduction: Moreover, an allosteric effect of the NTD mutations (L18F, D80A, D215G, Delta243-244 and R246) in the spike interaction with ACE2 has been suggested, because the binding of the Beta spike to the NTD-directed nAbs was dramatically reduced.
Introduction: This variant shares with the Beta variant some mutations with functional significance, which were acquired independently: E484K, N501Y, and K417T (instead of K417N found in Beta) located in the RBD, and L18F in the NTD.
Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together.
Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Result: L18F, H69del, V70del, D138Y and Y144del mutations were observed in NTD of S-protein of few isolates and these mutations could enhance the surface electropositivity of the S-protein and thereby facilitating the adhesion of virus to negatively charged lipid raft gangliosides of host cells.
Result: L18F, T19A, D80N, D138Y, Y144del, Y145del, K147E, N148S, W152 L, Q218H and S255F were found i
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Cell discovery
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