literature

SARS_CoV_2 mutation literature information.

GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.

PMID: 34388530 2021 Biomedicine & pharmacotherapy

Discussion: In addition, beta variant has more mutations in the N-terminal domain region of the spike protein:including L18F, D80A, D215G, LAL 242-244 del, and R246I:within or near flexible variable loops without modifying the structure of the functional domains of the spike protein.

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.

PMID: 34417590 2021 Nature immunology

Introduction: Acquisition of amino acid substitutions in the S RBD- namely K417N, E484K, and N501Y:and in the NTD, such as L18F, D80A, D215G, and Delta242-244, is associated with increased transmissibility and reduction in neutralization sensitivity.

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Table: L18F

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: P.1: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F.

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Table: L18F

An Autochthonous Outbreak of the SARS-CoV-2 P.1 Variant of Concern in Southern Italy, April 2021.

PMID: 34449757 2021 Tropical medicine and infectious disease

Introduction: These amino acid changes are L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F.

Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.

PMID: 34451453 2021 Pathogens (Basel, Switzerland)

Result: Fifteen substitutions (10 in the spike protein: L18F, T20N, P26S, D138Y, Discussion: The VOC P.1 carries three deletions, four synonymous substitutions, a four base-pair nucleotide insertion, and at least 17 other lineage-defining replacements, including 10 missense mutations in the spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I), 8 of which are subjected to positive selection.

Rise and Fall of SARS-CoV-2 Lineage A.27 in Germany.

PMID: 34452356 2021 Viruses

Result: <

Result: Among those, three alterations are of particular concern as they are located in the NTD or RBD epitope regions, respectively, and are suspected to result in immune escape (L18F, L452R and N501Y) and/or higher infectivity and transmissibility (L452R and N501Y).

Result: In total, A.27 harbors 17 lineage-defining mutations (Figure 3A and Figure 4A), seven of which result in non-synonymous nucleotide substitutions in the spike protein: L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V.

Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.

PMID: 34465019 2021 mBio

Table: L18F

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