Discussion: Notably, a spike mutation (L18F) affecting this region has shown strong signs of convergent evolution, being harbored by the variant of concern (VOC) P.1 and being present in a high proportion of VOC B.1.351 viruses.
SARS-CoV-2 in Transit: Characterization of SARS-CoV-2 Genomes From Venezuelan Migrants in Colombia.
PMID: 34333122
2021
International journal of infectious diseases
Abstract: A mutation (L18F) in the N-terminal domain of the spike protein that has been associated with compromised binding of neutralizing antibodies was found in 2 of 30 (6.6%) genomes.
Investigation of nonsynonymous mutations in the spike protein of SARS-CoV-2 and its interaction with the ACE2 receptor by molecular docking and MM/GBSA approach.
PMID: 34346317
2021
Computers in biology and medicine
Abstract: Using the extensive bioinformatics pipeline, we screened the destabilizing (L8V, L8W, L18F, Y145H, M153T, F157S, G476S, L611F, A879S, C1247F, and C1254F) and stabilizing (H49Y, S50L, N501Y, D614G, A845V, and P1143L) nonsynonymous mutations in the S-protein.
Result: As a meta result, i-stable predicted, out of 62 nonsynonymous mutations, 40 nonsynonymous m
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.
Introduction: For example, in B.1.351 and P.1 lineages, mutations in amino acid residues at positions 18 (L18F) and at position 417 (S417N, or S417T in some P.1 cases) were observed.
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Abstract: Among the identified mutations, NSP2_T153M, NSP14_I42V and Spike_L18F mutations showed a positive correlation to CFR.
Conclusion: Among the identified mutations,
Result: Among the identified mutations, NSP2_T153M, NSP14_I42V and Spike_L18F mutations showed a positive correlation to CFR (Figure 2A-C).
Result: The Spike_L18F mutation was reported at 16.02%, 0.72%, 1.86%, 10.90%, 1.25% and 5.94% in SARS-CoV-2 genome sequences isolated from Africa, Asia, Australia, Europe, North America and South America, respectively (Figure 2F).
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Discussion: Of the 10 new amino acid mutations in the spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) compared to its immediate ancestor (B.1.1.28), molecular selection analyses found evidence that 8 of these 10 mutations are under diversifying positive selection.
Molecular Evolution and Epidemiological Characteristics of SARS COV-2 in (Northwestern) Poland.
Result: The first one was DeltaH69V70 and N439 in lineage B.1.258 (20A), then D138Y with S477N observed for B.1.1.317 (20B), and finally A222V and L18F in the B.1.177 (20E EU1) strains.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Proc Natl Acad Sci U S A
Browser Board
Co-occurred Entities
Filtrator
ViMRT