Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant.
PMID: 34119826
2021
Biochemical and biophysical research communications
Introduction: The second variant of concern (VOC), B.1.351 (501Y.V2) first discovered in South Africa variant, has 9 mutations (L18F, D80A, D215G, Delta242-244, K417N, E484K, N501Y, D614G, and A701V).
Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic.
PMID: 34146731
2021
Infection, genetics and evolution
Introduction: Compared with the spike protein of SARS-CoV-2 Wuhan-1 strain, the spike protein of 501Y V2-3 contains eight mutations: four mutations in NTD (L18F, D80A, D215G, and Delta242-244), three mutations in viral RBD (K417N, E484K, and N501Y), and one mutation in S2 region (A701V).
Introduction: Thereafter, two other mutations L18F and K417N were identified in 501Y V2-1, resulting in strain 501Y V2-2.
Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.
Method: The variant B.1.351 (GISAID: EPI_ISL_700450) was constructed with 10 mutations including L18F, D80A, D215G, 242-244del, S305T, K417N, E484K, N501Y, D614G and A701V.
Method: The variant P.1 (GISAID: EPI_ISL_792681) was constructed with 12 mutations including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y
SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence.
Introduction: Five mutations are located within NTD (L18F, T20N, P26S, D138Y, R190S), three in RBD (K417T, E484K, N501Y), two in the C-terminal domain of S1 and near the furin cleavage site (D614G, H655Y), and one in S2 (T1027I) (Figure 3).
Anti-SARS-CoV-2 Vaccines and Monoclonal Antibodies Facing Viral Variants.
Introduction: It is characterized by four key mutations on Spike: L18F on N-Terminal-Domain (NTD); L452R on RBD, which could be involved in antibody neutralization escape and viral fitness improvement; N501Y (in common with 20I/501Y.V1); and H655Y (in common with 20J/501Y.V3), which could be involved in the Spike modulation and immune escape.
Introduction: It is characterized by the presence of 18 substitutions, among which 7 or 8 are located on the Spike protein, including L18F in NTD and L452R in RBD, which are also present in 20J/501Y.V3, 20H/501Y.V2, and CAL.20C variants,
A Comprehensive Molecular Epidemiological Analysis of SARS-CoV-2 Infection in Cyprus from April 2020 to January 2021: Evidence of a Highly Polyphyletic and Evolving Epidemic.
Abstract: Genetic analysis of whole SARS-CoV-2 genomic sequences of the aforementioned lineages revealed the presence of mutations within the S protein (L18F, DeltaH69/V70, S898F, DeltaY144, S162G, A222V, N439K, N501Y, A570D, D614G, P681H, S982A and D1118H) that confer higher transmissibility and/or antibody escape (immune evasion) upon the virus.
Introduction: Furthermore, mutations/deletions in the S-protein, such as L18F, DeltaH69/V70, PMID: 34220844
2021
Frontiers in immunology
Discussion: D614G+L18F+A222V and D614G+A222V were the main epidemic variants before the emergence of VOC-202012/01.
Discussion: Both the D614G+L18F+A222V and D614G+A222V variants showed increased sensitivity to convalescent sera and sera elicited by inactivated-virus vaccines, which may be caused by the A222V mutation.
Discussion: Furthermore, the L18F mutation is a
Discussion: This study showed that A222V was more sensitive to most mAbs, whereas L18F was slightly resistant to some mAbs.
Genomic monitoring unveil the early detection of the SARS-CoV-2 B.1.351 (beta) variant (20H/501Y.V2) in Brazil.
Result: P.1 defining mutations related to each genomic region were the following: ORF1ab: S1188L, K1795Q, E5665D; spike: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I; Orf8: E92K; and nucleocapsid: P80.
Updated SARS-CoV-2 single nucleotide variants and mortality association.
Result: S: Result: Another mutation C21614T (S:L18F) in the emerging group A.E3 SNV is located in N-linked glycan sites, which likely play a role in protein folding and immune evasion and may have implications in viral virulence and vaccine design.
Result: Four SNVs in groups A.E1-A.E3 are nonsynonymous variants, including ORF10:V30L (G29645T), N:A220V (C28923T), and two on S protein, A222V (C22227T) and L18F (C21614T) (Figure 1A).
SARS_CoV_2 mutation literature information.
PMID: 
2021
Biochemical and biophysical research communications
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