literature

SARS_CoV_2 mutation literature information.

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern.

PMID: 33925854 2021 Microorganisms

Result: The BR-VOC is highly mutated in the S-gene resulting in 12 aa substitutions in the S-protein including L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, and V1176F.

Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

PMID: 33975397 2021 Journal of Korean medical science

Introduction: The SARS-CoV-2 B.1.351 variant in South Africa has eight mutations involving the S protein (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, and A701V).

Method: Among these mutations, five (L18F, S98F, A262S, A222V, and P272L) occurred in the N-terminal domain (NTD) of the S protein, and five (N439K, Y453F, S477N,

Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage.

PMID: 33991677 2021 Clinical microbiology and infection

Abstract: RESULTS: We identified that SARS-CoV-2 genomes from four patients diagnosed in our institute harboured a new set of amino acid substitutions including L18F, L452R, N501Y, A653V, H655Y, D796Y, G1219V +- Q677H.

Result: In addition, sequences that span codons 1-618 of the spike gene and allow the identification of this variant by covering 4 of its hallmark mutations (C21614T (substitution L18F), G22468T, T22917G (L452R), A23063T (

Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.

PMID: 34021265 2021 Cell research

Introduction: 501Y.V2 is associated with multiple S mutations, which could be divided into two main subsets, one is clustered in NTD (L18F, D80A, D215G, 242-244Delta, and R246I), and the other is clustered in RBD (K417N, E484K, and N501Y).

E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

PMID: 34044192 2021 Infection, genetics and evolution

Result: Regarding the lineage-defining mutations from P.1 lineages, 14 of a total of 19 genomes from the Amazonas monophyletic group present the spike mutations L18F, T20N, P26S, D138Y, and R190S.

Table: L18F

Convalescent-Phase Sera and Vaccine-Elicited Antibodies Largely Maintain Neutralizing Titer against Global SARS-CoV-2 Variant Spikes.

PMID: 34060334 2021 mBio

Introduction: The B.1.351 lineage variant identified in South Africa that has become the predominant genotype in that population is more heavily mutated than B.1.1.7, with 9 mutations (L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, and A701V), 3 of which (K417N, E484K, and N501Y) are in the receptor binding domain (RBD).

Table: L18F

Molecular Analysis of SARS-CoV-2 Circulating in Bangladesh during 2020 Revealed Lineage Diversity and Potential Mutations.

PMID: 34065789 2021 Microorganisms

Result: The other significant S protein mutations observed at the N-terminal domain (NTD) were L18F (n = 1), His69del (n = 5), V70del (n =

Discussion: Bangladeshi strains exhibited other S protein mutations or variants, as well as combined variants, such as L5F, L18F, N354S, A520K, Q675H/R, P681H/R, L5F + D614G, and D614G + M1229Y, which have been previously linked with increased infectivity under experimental setups and may have significant biological properties in response to natural infection.

The Spike of Concern-The Novel Variants of SARS-CoV-2.

PMID: 34071984 2021 Viruses

Introduction: Variant B.1.351-V2 carries one additional N-terminal mutation, L18F, which is also present in the Brazilian P.1 virus, and variant B.1.351-V3, which harbours the R246I mutation in loop N5 but lacks the D215G replacement (Table 1).

SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection.

PMID: 34109031 2021 Annals of medicine and surgery (2012)

Introduction: These mutations are L18F, T20N, P26S, D138Y, R190S, D614G H655Y, T1027I, and V1176F.

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant.

PMID: 34119826 2021 Biochemical and biophysical research communications

Introduction: The second variant of concern (VOC), B.1.351 (501Y.V2) first discovered in South Africa variant, has 9 mutations (L18F, D80A, D215G, Delta242-244, K417N, E484K, N501Y, D614G, and A701V).

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