literature

SARS_CoV_2 mutation literature information.

Epidemiology of COVID-19: An updated review.

PMID: 34759999 2021 Journal of research in medical sciences

Table: L18F

Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.

PMID: 34726786 2021 Journal of medical virology

Table: L18F

SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.

PMID: 34601723 2021 The EMBO journal

Result: The Beta S is comprised of the L18F, D80A, D215G, and 242-244 mutations in the NTD, K417N and E484K mutations in the receptor-binding domain (RBD), and A701V in the S1/S2 cleavage site.

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Figure: * The codes on the x and y axes of the matrix include: s001A: 20A, s002A: 19A, s003A: 20A/S.A262S, s004A: 20A/S.A701V, s005A: 20A/S.D80A, s006A: 20A/S.E484K, s007A: 20A/S.E484Q, s008A: 20A/S.K417 N, s009A: 20A/S.L452R, s010A: 20A/S.N501T, s011A: 20A/S.N501Y, s012A: 20A/S.P681H, s013A: 20A/S.P681R, s014A: 20A/S.Q675H, s015A: 20A/S.Q675P, s016A: 20A/S.Q677H, s017A: 20A/S.Q677P, s018A: 20A/S.V1176F, s019A: 20A/S.A222V, s020A: 20A/S.

Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity.

PMID: 34536797 2021 Virology

Result: Our results show that all the NTD mutations, namely L18F, T20N, P26S, D138Y and R190S, attenuated the binding of naive-vaccinated plasma Abs.

Result: While we did not observe a significant decrease in plasma recognition of the B.1.351 Spike, most single mutants of this VOC (L18F, D80A, D215G, Delta242-244, R246I in the NTD, and K417N in the RBD) exhibit decreased binding.

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.

PMID: 34537136 2021 Cell

Result: An F at residue S/18 is also observed in 10% of other known Sarbecoviruses and the L18F mutation was the 28th most common in sampled SARS-CoV-2 genomes on June 4, 2021.

Result: In addition to the 29 convergent mutations that displayed frequency increases between March 15 and June 1, 2021, the meta-signature includes deletion mutations at ORF1a/3675-3677, S/69-70, S/144, and S/241-243 (which, while displaying convergence between the different 501Y lineages, were not amenable to selection analyses) and the convergent signature substitutions L18F, K417N/K, and N501Y (which were already at high frequencies in multiple 501Y lineages by March 15, 2021).

Result: S/18 falls within multiple different predicted CTL epitopes and the L18F mutation is known to reduce viral

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: L18F

Mutational profile confers increased stability of SARS-CoV-2 spike protein in Brazilian isolates.

PMID: 34633892 2021 Journal of biomolecular structure & dynamics

Abstract: Most of the SARS-CoV-2 isolates belongs to the G clade and showed a large occurrence of D614G, N501Y and L18F substitutions.

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: Dual mutants containing D614G and other amino acid changes, including those under positive selection or observed in VOCs (L5F, L18F, S98F, W152L/C, E154K, L222V, and A262S in S1-NTD; N439K, L452Q/R, S477N, L478R/K, E484K/Q, N501Y, and A570D within S1-RBD; Q677H/P and P681H/R in S1-CTD; T716I,

Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.

PMID: 34688376 2021 Cell host & microbe

Method: SARS-CoV-2 pseudotyped lentiviruses were prepared by co-transfecting the HEK293T cell line with either the SARS-CoV-2 ancestral variant spike (D614G), the Beta spike (L18F, D80A, D215G, K417N, E484K, N501Y, D614G, A701V, 242-244 del) or the Delta spike (T19R, R158G L452R, T478K, D614G, P681R, D950N, 156-157 del) plasmids in co

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