literature

SARS_CoV_2 mutation literature information.

SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene.

PMID: 34796036 2021 Immune network

Table: L18F

Mutation-Induced Long-Range Allosteric Interactions in the Spike Protein Determine the Infectivity of SARS-CoV-2 Emerging Variants.

PMID: 34805715 2021 ACS omega

Introduction: For example, the P.1 lineage detected first in Brazil is characterized by several amino acid (AA) substitutions mostly located either in RBD or in NTD: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I, which are shown to reduce neutralization by some antibodies.

Table: L18F

A rigorous framework for detecting SARS-CoV-2 spike protein mutational ensemble from genomic and structural features.

PMID: 34806033 2021 Current research in structural biology

Result: For instance, L18F, T20N, P26S, D138Y, and R190S are present in P.1 lineage.

Result: For the characteristic NTD mutations across VoCs (L18F, T19R, T20N, D80A, and T95I), we observed the MTR score of0.738 suggesting that these mutations show a neutral impact on the protein structure.

Result: Specifically, L18F, T19R, and T20N are present in the N-terminus epitope, whereas G142D, W152 R/L/C,

PMID: 34846283 2021 Microbial genomics

Result: Among these results, although not at a high frequency, cases of T478K co-occurring with other spike protein mutations of concern could be detected, including: (i) K417N, which is present in 20h/501Y.V2 or B.1.351, identified in one sample (February 2021, GISAID EPI ISL 1137473); (ii) L18F, which is present in 20J/501Y.V3 or P.1, identified in one sequence from the State of Oaxaca, in the parental lineage B.1 (January 2021, GISAID EPI ISL 1168605); and (iii) the deletion of an amino acid in position 144, which occurs in 20I/501Y.V1 or B.1.1.7 and 20A/S.484K or B.1.525, in one sample from Mexico City (February 2020, GISAID EPI ISL 1181713).

Result: For instance, mutation L18F is a mutation of concern as it occurs in variants 20h/501Y.V2 or B.1.351 and 20J/501Y.V3 or P.1 and has been implicated in antibody scape.

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure.

PMID: 34871297 2021 PloS one

Result: All mutations except L18F were distributed well in all four regions but the number of L18F mutations was close to zero in Turkey when compared to other continents (Fig 3B).

Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal.

PMID: 34880295 2021 Scientific reports

Introduction: Likewise, the other lineage defining mutations for variants of concern were absent in the A.27 genomes, with the exception of L18F and H655Y, which are both present in the gamma lineage.

Local occurrence and fast spread of B.1.1.7 lineage: A glimpse into Friuli Venezia Giulia.

PMID: 34905574 2021 PloS one

Table: p.L18F

Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals.

PMID: 34910734 2021 PloS one

Result: Some mutations in S protein like L54F, P681L, L18F, S494P, Q613H, L560P, T299A, V1104L, L1063F, Q675R, D138Y, A522S, A845S were only detected in cat, not in any other animal species.

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection.

PMID: 34923570 2021 Cell discovery

Method: pS-B.1.1.7 and pS-B.1.351 plasmids were constructed with mutant S genes expressing the spike protein of the B.1.1.7 variant (GenBank: QQH18545.1, containing the H69, V70, and Y145 deletions and N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H mutations) and B.1.351 variant (GenBank: QRI43207.1, containing the L242, A243, and L244 deletions and L18F, D80A, D215G, S305T, K417N, E484K, N501Y, D614G

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.

PMID: 34925381 2021 Frontiers in immunology

Introduction: The Beta (B.1.351) variant encodes an S protein with nine mutations (L18F, D80A, D215G, Del 241-243, K417N, E484K, N501Y, D614G and A701V, three of which (K417N, E484K and N501Y) are in the RBD.

Introduction: The Gamma P.1 variant encodes an S protein with 12 mutations (L18F, T20N, P26S, D138Y, R190S,

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