Introduction: The Beta variant contained spike mutations L18F, D80A, D215G, Delta242-244, R246I, K417N, E484K, N501Y and A701V.
The Development of SARS-CoV-2 Variants: The Gene Makes the Disease.
PMID: 34940505
2021
Journal of developmental biology
Introduction: Moreover, an allosteric effect of the NTD mutations (L18F, D80A, D215G, Delta243-244 and R246) in the spike interaction with ACE2 has been suggested, because the binding of the Beta spike to the NTD-directed nAbs was dramatically reduced.
Introduction: This variant shares with the Beta variant some mutations with functional significance, which were acquired independently: E484K, N501Y, and K417T (instead of K417N found in Beta) located in the RBD, and L18F in the NTD.
Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together.
Phylodynamic Pattern of Genetic Clusters, Paradigm Shift on Spatio-Temporal Distribution of Clades, and Impact of Spike Glycoprotein Mutations of SARS-CoV-2 Isolates from India.
PMID: 35017872
2021
Journal of global infectious diseases
Result: L18F, H69del, V70del, D138Y and Y144del mutations were observed in NTD of S-protein of few isolates and these mutations could enhance the surface electropositivity of the S-protein and thereby facilitating the adhesion of virus to negatively charged lipid raft gangliosides of host cells.
Result: L18F, T19A, D80N, D138Y, Y144del, Y145del, K147E, N148S, W152 L, Q218H and S255F were found i
Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.
SARS_CoV_2 mutation literature information.
PMID: 
2021
medRxiv
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