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 SARS_CoV_2 mutation literature information.


  Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda.
 PMID: 34230931       2022       bioRxiv
Abstract: The A.23 viral lineage, characterized by three spike mutations F157L, V367F and Q613H, was first identified in COVID-19 cases from a Ugandan prison in July 2020, and then was identified in the general population with additional spike mutations (R102I, L141F, E484K and P681R) to comprise lineage A.23.1 by September 2020, with this virus being designated a variant of interest (VOI) in Africa and with subsequent spread to 26 other countries.
Introduction: This lineage then spilled into the general population adding additional spike mutations (R102I,  PMID: 35308337       2022       Frontiers in microbiology
Result: Supplementary Figure S5 showed the 7 amino acid changes in the Spike of virus detected in the last sample: S12F, T95I, L141F, E484Q, S494L, D614G, and I770V.
Result: The Spike structure showed a signal peptide mutation, S12F, and two changes in the N-terminal domain (NTD), T95I and L141F.
Discussion: The spike structure showed different changes: (i) a signal peptide mutation, S12F; (ii) two changes in the N-terminal domain,



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