Figure: Effect of Delta682-686 and
K814A mutations on SARS-CoV-2 infectivity of lung cell line and human ACE2 transgenic mice.
Discussion: Cell-cell fusion studies suggested that both the
K814A site and the 682-686 sites are important for furin-enhanced cell-cell fusion, with the 682-686 sites necessary for furin functioning in donor cells.
Discussion: The
K814A single mutation led to a complete loss of the furin-mediated infectivity enhancement, suggesting its important role during furin functioning (Figure 2D).
SARS_CoV_2 mutation literature information.
PMID: 
2022
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