Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Abstract: We report that the RBD of the Alpha (N501Y) variant requires the highest amount of force initially to be detached from ACE2 due to the N501Y mutation in addition to the role of N90-glycan, followed by Beta/Gamma (K417N/T, E484K, and N501Y) or Delta (L452R and T478K) variant.
Introduction: K417N/T mutations of Beta and Gamma appear to make the RBD-ACE2 interactions less strong compared to Alpha variant.
Introduction: Gamma variant also shows decreased contact numbers similar to Beta due to its K417T mutation (Figure S2A).
Introduction: The only difference between Gam
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.
Result: However, mutations like K417N and K417T were not observed to cause favourable changes on expression (a proxy measurement for stability) or binding as well as immune recognition, but in our high throughput evaluation they were, as well as several substitutions in this position, predicted to increase the occupancy of the open state.
Result: P.1 variant includes the mutations L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I.
SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India.
Introduction: These variants are known to possess multiple mutations across the genome, including several in the S protein and its RBD, such as N501Y, E484K and K417N/T.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Introduction: It has the same three mutations (except for K417T instead of K417N) in RBD as B.1.351, but it arose independently.
Discussion: Of the 10 new amino acid mutations in the spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) compared to its immediate ancestor (B.1.1.28), molecular selection analyses found evidence that 8 of these 10 mutations are under diversifying positive selection.
Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater.
PMID: 34371414
2021
The Science of the total environment
Abstract: It also indicates that RT-ddPCR could be used for sensitive and accurate monitoring of current (like K417N, K417T, E484K, L452R) or future mutations present in SARS-CoV-2 variants of concern.
Discussion: E484K, K417T, K417N or L452R) characteristic for various epidemiologically or immunologically relevant VoC's.
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
Precision Response to the Rise of the SARS-CoV-2 B.1.1.7 Variant of Concern by Combining Novel PCR Assays and Genome Sequencing for Rapid Variant Detection and Surveillance.
Discussion: Assays that target S gene mutations such as E484K, K417N, K417T, L452R, the Y144 deletion, and the 242 to 244 deletion, and the ORF1ab gene 3675 to 3677 deletion, are in development.
Abstract: Our analysis suggests that B.1.1.7, B.1.351, and P.1 are more easily spreading than other variants, and the key mutations of S protein, including N501Y, E484K, and K417N/T, have high mutant frequencies, which may have become the main genotypes for the spread of SARS-CoV-2.
Result: It has 17 unique amino acid changes, 3 deletions, 4 synonymous mutations, and one 4nt insertion, including three mutations in the RBD of S protein: K417T, E484K, N501Y.
Result: So N501Y, E484K, and K417N/T may have become the main genotypes for the spread of SARS-Co
SARS_CoV_2 mutation literature information.
PMID: 
2021
ACS omega
Browser Board
Co-occurred Entities
Filtrator
ViMRT