Result: However, in this case, our results predict that both mutants (K417N and K417T) could destabilize the protein and increase local flexibility.
Table: K417T
SARS-CoV-2 testing and sequencing for international arrivals reveals significant cross border transmission of high risk variants into the United Kingdom.
Introduction: The combination of nearby RBD mutations K417N/T, E484K and N501Y found in B.1.351 (South Africa) and P.1 (Brazil) make these particularly concerning variants.
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.
Abstract: We constructed nanobody tandems and identified nanobody monomers that tolerate the K417N/T, E484K, N501Y, and L452R immune-escape mutations found in the Alpha, Beta, Gamma, Epsilon, Iota, and Delta/Kappa lineages.
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.
Introduction: The S genes of B.1.351 and P.1 viruses each carry a number of mutations, but include three in the receptor binding domain (RBD) that are particularly notable, the S: N501Y substitution, found in B.1.1.7, alongside polymorphisms at positions 417 and 484, K417N/T and E484K.
Discussion: B.1.351 and P.1 have in common three RBD substitutions (K417N/T, E484K and N501Y) whereas B.1.351, P.1 and B.1.1.7 contain the N501Y substitution.
The challenge of screening SARS-CoV-2 variants of concern with RT-qPCR: One variant can hide another.
PMID: 34332998
2021
Journal of virological methods
Abstract: From week 18 we used in addition the new NovaplexSARS-CoV-2 Variants II Assay for samples with no targets found with the Variants I assay or with the mutation E484K alone, in order to screen the mutations L452R, K417N/T
Discussion: It distinguishes the VOC B.1.351 from the VOC P.1 by amplification of the K417N and K417T mutations respectively when both the N501Y and E484K mutations were found positive with the Variant I Assay.
Discussion: Since early May 2021, a new NovaplexSARS-CoV-2 Variants II Assay has been available on the market to detect L452R, K417N, K417T and W152C mutations.
Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV-2 Strains using SSSCPreds.
Abstract: We report that the RBD of the Alpha (N501Y) variant requires the highest amount of force initially to be detached from ACE2 due to the N501Y mutation in addition to the role of N90-glycan, followed by Beta/Gamma (K417N/T, E484K, and N501Y) or Delta (L452R and T478K) variant.
Introduction: K417N/T mutations of Beta and Gamma appear to make the RBD-ACE2 interactions less strong compared to Alpha variant.
Introduction: Gamma variant also shows decreased contact numbers similar to Beta due to its K417T mutation (Figure S2A).
Introduction: The only difference between Gam
Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants.
Result: However, mutations like K417N and K417T were not observed to cause favourable changes on expression (a proxy measurement for stability) or binding as well as immune recognition, but in our high throughput evaluation they were, as well as several substitutions in this position, predicted to increase the occupancy of the open state.
Result: P.1 variant includes the mutations L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I.
SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India.
Introduction: These variants are known to possess multiple mutations across the genome, including several in the S protein and its RBD, such as N501Y, E484K and K417N/T.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Introduction: It has the same three mutations (except for K417T instead of K417N) in RBD as B.1.351, but it arose independently.
Discussion: Of the 10 new amino acid mutations in the spike protein (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I) compared to its immediate ancestor (B.1.1.28), molecular selection analyses found evidence that 8 of these 10 mutations are under diversifying positive selection.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of medical virology
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