literature

SARS_CoV_2 mutation literature information.

E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.

PMID: 34044192 2021 Infection, genetics and evolution

Table: K417T

The Spike of Concern-The Novel Variants of SARS-CoV-2.

PMID: 34071984 2021 Viruses

Introduction: Both the K417T and K417N mutations abolish this bond and are therefore predicted to have a lower hAce2 affinity while helping to evade neutralizing antibodies.

Introduction: P.1 Spike contains 12 amino acid changes of which K417T, E484K, and N501Y are key positions with a high degree of structural and energetic plasticity that can accommodate novel residues with altered Ace2-interaction potentials (Table 1).

Introduction: Whether this applies also to the K417T mutation is not yet clear, but it is likely, as K417 is a major site in the RBD with long-range, inter-molecular links throughout spike (Table 2).

501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro.

PMID: 34074219 2021 mAbs

Introduction: However, this same N501Y mutation is also found in a variant (B.1.351, 20 H/501Y.V2) with mutations of K417N, E484K, and N501Y from South Africa and a variant (P1, 20 J/501Y.V3) with K417T, E484K, and N501Y from Brazil with additional mutations within the RBD.

Introduction: The two additional mutations, K417N/T and E484K, are also critical residues involved in the interactions between RBD and ACE2, as well as bamlanivimab.

Discussion: The introduction of K417T existing from the Brazilian variant should lead to the similar drop due to the los

Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.

PMID: 34081630 2021 JCI insight

Discussion: All 3 VOCs harbor an N501Y mutation within S-RBD, while the B.1.351 and P.1 variants contain 2 additional RBD changes, K417N/T and E484K.

Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan.

PMID: 34097716 2021 PLoS pathogens

Result: We previously identified P.1 lineage SARS-CoV-2, which harbors the K417T/E484K/N501Y mutations, in one patient.

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.

PMID: 34098567 2021 Nature

Introduction: P.1, a third variant that spread rapidly in Brazil, shows changes similar to those of B.1.1.7 and B.1.351: N501Y, K417T and E484K.

Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.

PMID: 34103090 2021 European journal of medical research

Table: K417T

SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection.

PMID: 34109031 2021 Annals of medicine and surgery (2012)

Abstract: The essential modifications located in the spike glycoprotein RBD include E484K, K417T and N501Y.

Introduction: The essential mutations in the spike include the glycoprotein RBD, E484K, K417T, and N501Y.

Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination.

PMID: 34120577 2021 Emerging microbes & infections

Result: For Brazil P.1 with three RBD mutations (K417T/E484K/N501Y), only 1H1 was found to mediate neutralization in our study.

Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021.

PMID: 34128696 2021 mSystems

Introduction: Amino acid substitutions at residue 417, K417N in B.1.351 and K417T in P.1, appear to improve evasion from antibodies in combination with N501Y and E484K.

Introduction: B.1.351 and P.1 variants have two more spike mutations of biological significance: E484K and K417N/T, both located in the RBD and both important for ACE-2 binding and antibody recognition.

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