Introduction: Interestingly, the gamma and beta lineages share three common mutations (K417N/T, E484K, and N501Y) in spike protein.
Introduction: The K417N/T, E484K, and N501Y mutations significantly decreased the neutralizing activity of convalescent and messenger RNA vaccine-induced serum.
Introduction: The gamma variant was first detected in Manaus, Brazil in November, 2020 with the following lineage-defining mutations: E484K, K417T, and N501Y.
Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity.
PMID: 34722330
2021
Frontiers in cellular and infection microbiology
Introduction: Interestingly, N501Y.V3 (also known as P.1) lineage in Brazil almost has the same three RBD mutations as N501Y.V2 lineage, except for the K417N/T substitution.
Discussion: Indeed, N501Y.V3 lineage includes three mutations in the RBD region (K417T, E484K and N501Y), and it almost has the same three mutations present in RBD as N501Y.V2 lineage, except for K417N/T substitution.
Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization.
Result: K417N/T and N501Y also cause minor changes in local structure, which further weakens the affinity between CDRL and RBD, especially Y503 on RBD.
Result: K417N/T destroys the salt bridge, thus reducing the affinity significantly.
Result: Additionally, the K417N/T mutation caused reduced neutralization activity involving five mAbs (1F9, 2H10, 10D12, CB6, and A247), whereas it increased the neutralization sensitivity of one mAb (A261-262) for more than ten times.
Result: Furthermore, the neutralization activity against the K417T/N single-mutation strain was increased among all serum samples.
Result: Single mutation analyses showed that K417T, PMID: 34637549
2021
FASEB journal
Discussion: The clusters share some of the mutations linked with viral escape, including N501Y (Alpha, Beta, and Gamma), E484K (Beta and Gamma) and K417N/T (Beta and Gamma).
Variants of SARS-CoV-2, their effects on infection, transmission and neutralization by vaccine-induced antibodies.
PMID: 34604978
2021
European review for medical and pharmacological sciences
Abstract: S477N, E484K, Q677H, E484Q, L452R, K417T, K417N and N501Y.
SARS-CoV-2 Virus-Host Interaction: Currently Available Structures and Implications of Variant Emergence on Infectivity and Immune Response.
PMID: 34639178
2021
International journal of molecular sciences
Discussion: Mutation K417T deletes a salt bridge with D30 from hACE2, potentially leading to a decreased affinity.
Discussion: One of the defining characteristics of this variant is the high number of mutations, particularly in the spike protein, with three mutations specific to the RBD (K417T, E484K and N501Y), that lead to a 19-fold increase in affinity compared to the Wuhan strain.
Molecular rationale for SARS-CoV-2 spike circulating mutations able to escape bamlanivimab and etesevimab monoclonal antibodies.
Result: As such, it is not surprising that replacing K417 on the viral protein with each of the alternative circulating mutants (K417E/N/R/T) reflects into a very strong interface disrupting behavior, with the exception of the substitution K417R, for which our in silico mutagenesis data anticipate a neutral effect.
Result: As such, the variation in bi
Discussion: In agreement with this and other evidences, our current computational alanine/mutagenesis study marks K417 and all its reported variants (K417E/N/R/T) as the strongest hot spots in eliciting potential escape to the LY-CoV016 mAb.
Discussion: Of note, the K417N and K417T in particular are spike MOIs in the SARS-CoV2 VOC lineages B.1.351 (Beta) and P.1 (Gamma), respectively.
The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America.
3Introduction: Moreover, we have pointed out that Y449S and Y449H are two vaccine-resistant mutations, and ""Y449S, S494P, K417N,
Introduction: Later on, we have provided a list of most likely vaccine escape RBD mutations with high frequency, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.
Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in Brazil.
Introduction: In addition to E484K, P.1 harbors the N501Y and K417T mutations in the RBD region.
Result: We found 16 SNVs targeting the receptor-binding domain (RBD) in S1, of which eight were missense variants, including K417T, N439K, L452R, S477R, E484K, N501Y, L518I, A522V.
Emerging SARS-CoV-2 variants expand species tropism to murines.
Result: 1e-g), suggesting the K417N/T and E484K mutation in the RBD of these variants might further facilitate mouse adaptation in addition to the N501Y substitution.
SARS_CoV_2 mutation literature information.
PMID: 
2021
Journal of medical virology
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