literature

SARS_CoV_2 mutation literature information.

Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein.

PMID: 34414884 2021 eLife

Discussion: Interestingly, three key mutations (N501Y, E484K, and K417T) are found in the RBD of the P.1 variant.

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum.

PMID: 34419925 2021 EBioMedicine

Introduction: The B.1.351 and P.1 variants also contain mutation at the spike amino acid position 484 (E484K) and at position 417 (K417N for B.1.351; K417T for P.1).

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Table: K417T

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: P.1: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F.

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics.

PMID: 34435953 2021 eLife

Table: K417T

Discussion: It is notable that these affinity-reducing K417N/T mutations have only emerged together with mutations (N501Y and E484K) that increase the affinity of RBD for ACE2, suggesting a cooperative effect between mutations that enhance immune escape and mutations that increase affinity.

Discussion: Our affinity and kinetic data on RBD variants are broadly consistent with some, but not all, recent reports on the K417T/N, N501Y, and E484K variants.

Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.

PMID: 34438144 2021 The Science of the total environment

Table: K417T

Molecular Dynamics Simulation Study of the Interaction between Human Angiotensin Converting Enzyme 2 and Spike Protein Receptor Binding Domain of the SARS-CoV-2 B.1.617 Variant.

PMID: 34439910 2021 Biomolecules

Introduction: The variant P.1, originally reported in Brazil, harbors N501Y, E484K, K417T mutations in the S protein.

Impact of Full Vaccination with mRNA BNT162b2 on SARS-CoV-2 Infection: Genomic and Subgenomic Viral RNAs Detection in Nasopharyngeal Swab and Saliva of Health Care Workers.

PMID: 34442817 2021 Microorganisms

Abstract: Moreover, concordance was observed between NPS and saliva in the detection of viral mutations, and both N501Y and 69/70del (associated with the B.1.1.7 variant) were detected in the majority 6/8 (75%) of subjects, while the K417T mutation (associated with the P.1-type variants) was detected in 2/8 (25%) individuals.

Method: Moreover, the RT-PCR method was used for the analysis of known viral mutations using the REALQUALITY SARS-CoV-2 Variants (AB ANALITICA, Padova, Italy) (targeting N501Y, K417T and K417N) and SARS-CoV-2 Nucleic Acid Mutation Diagnostic kit (Sansure Biotech Inc, Hunan, China) (targeting N501Y and HV69/70del), following the manufacturers' instructions.

Discussion: Two others that were symptomatic (one with myalgia and the B.1.1.7 variant, and one wi

Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.

PMID: 34448936 2021 Archives of virology

Introduction: These SARS-CoV-2 VOCs have acquired some of the same spike protein mutations independently, particularly E484K, N501Y, S477N, and K417T, which have been associated with increased viral transmission and/or decreased sensitivity to antibody neutralization.

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