literature

SARS_CoV_2 mutation literature information.

Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater.

PMID: 34371414 2021 The Science of the total environment

Abstract: It also indicates that RT-ddPCR could be used for sensitive and accurate monitoring of current (like K417N, K417T, E484K, L452R) or future mutations present in SARS-CoV-2 variants of concern.

Discussion: E484K, K417T, K417N or L452R) characteristic for various epidemiologically or immunologically relevant VoC's.

Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

PMID: 34373458 2021 Nature communications

Table: K417T

Precision Response to the Rise of the SARS-CoV-2 B.1.1.7 Variant of Concern by Combining Novel PCR Assays and Genome Sequencing for Rapid Variant Detection and Surveillance.

PMID: 34378966 2021 Microbiology spectrum

Discussion: Assays that target S gene mutations such as E484K, K417N, K417T, L452R, the Y144 deletion, and the 242 to 244 deletion, and the ORF1ab gene 3675 to 3677 deletion, are in development.

Controversy surrounding the Sputnik V vaccine.

PMID: 34399368 2021 Respiratory medicine

Introduction: Gamma variant has three changes in the S RBD (K417T, E484K, and N501Y).

The Emergence and Spread of Novel SARS-CoV-2 Variants.

PMID: 34409009 2021 Frontiers in public health

Abstract: Our analysis suggests that B.1.1.7, B.1.351, and P.1 are more easily spreading than other variants, and the key mutations of S protein, including N501Y, E484K, and K417N/T, have high mutant frequencies, which may have become the main genotypes for the spread of SARS-CoV-2.

Result: It has 17 unique amino acid changes, 3 deletions, 4 synonymous mutations, and one 4nt insertion, including three mutations in the RBD of S protein: K417T, E484K, N501Y.

Result: So N501Y, E484K, and K417N/T may have become the main genotypes for the spread of SARS-Co

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2.

PMID: 34414884 2021 eLife

Discussion: Interestingly, three key mutations (N501Y, E484K, and K417T) are found in the RBD of the P.1 variant.

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum.

PMID: 34419925 2021 EBioMedicine

Introduction: The B.1.351 and P.1 variants also contain mutation at the spike amino acid position 484 (E484K) and at position 417 (K417N for B.1.351; K417T for P.1).

SARS-CoV-2 reinfection in a healthcare professional in inner Sao Paulo during the first wave of COVID-19 in Brazil.

PMID: 34425504 2021 Diagnostic microbiology and infectious disease

Table: K417T

Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.

PMID: 34430803 2021 iScience

Method: Antibody preparations were evaluated by SARS-CoV-2 pseudovirus neutralization assay (PsVNA) using WA-1 strain, UK variant (B.1.1.7 with spike mutations: H69-V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H), SA variant (B.1.351 strain with spike mutations L18F, D80A, D215G, L242-244del, R246I, K417N, E484K, N501Y, D614G, and

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.

PMID: 34433803 2021 Signal transduction and targeted therapy

Method: P.1: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F.

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