Discussion: It is notable that these affinity-reducing K417N/T mutations have only emerged together with mutations (N501Y and E484K) that increase the affinity of RBD for ACE2, suggesting a cooperative effect between mutations that enhance immune escape and mutations that increase affinity.
Discussion: Our affinity and kinetic data on RBD variants are broadly consistent with some, but not all, recent reports on the K417T/N, N501Y, and E484K variants.
Discussion: Our finding that the K417N/T mutations present in Beta and Gamma variants decrease the affinity of RBD
Community-level SARS-CoV-2 sequence diversity revealed by wastewater sampling.
PMID: 34438144
2021
The Science of the total environment
Table: K417T
Molecular Dynamics Simulation Study of the Interaction between Human Angiotensin Converting Enzyme 2 and Spike Protein Receptor Binding Domain of the SARS-CoV-2 B.1.617 Variant.
Introduction: The variant P.1, originally reported in Brazil, harbors N501Y, E484K, K417T mutations in the S protein.
Impact of Full Vaccination with mRNA BNT162b2 on SARS-CoV-2 Infection: Genomic and Subgenomic Viral RNAs Detection in Nasopharyngeal Swab and Saliva of Health Care Workers.
Abstract: Moreover, concordance was observed between NPS and saliva in the detection of viral mutations, and both N501Y and 69/70del (associated with the B.1.1.7 variant) were detected in the majority 6/8 (75%) of subjects, while the K417T mutation (associated with the P.1-type variants) was detected in 2/8 (25%) individuals.
Method: Moreover, the RT-PCR method was used for the analysis of known viral mutations using the REALQUALITY SARS-CoV-2 Variants (AB ANALITICA, Padova, Italy) (targeting N501Y, K417T and K417N) and SARS-CoV-2 Nucleic Acid Mutation Diagnostic kit (Sansure Biotech Inc, Hunan, China) (targeting N501Y and HV69/70del), following the manufacturers' instructions.
Discussion: Two others that were symptomatic (one with myalgia and the B.1.1.7 variant, and one wi
Emergence and spread of the potential variant of interest (VOI) B.1.1.519 of SARS-CoV-2 predominantly present in Mexico.
Introduction: These SARS-CoV-2 VOCs have acquired some of the same spike protein mutations independently, particularly E484K, N501Y, S477N, and K417T, which have been associated with increased viral transmission and/or decreased sensitivity to antibody neutralization.
An Autochthonous Outbreak of the SARS-CoV-2 P.1 Variant of Concern in Southern Italy, April 2021.
PMID: 34449757
2021
Tropical medicine and infectious disease
Introduction: These amino acid changes are L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F.
Method: SGTF-negative samples were screened for the presence of notable types of spike protein mutations (HV 69-70 dele
Result: Therefore, samples were subjected to molecular screening for variants and designated the P.1 variant because of the presence of the K417T, E484K, and N501Y spike mutations.
Predominance of the SARS-CoV-2 Lineage P.1 and Its Sublineage P.1.2 in Patients from the Metropolitan Region of Porto Alegre, Southern Brazil in March 2021.
Introduction: Since the P.1 variant carries multiple mutations of potential biological significance (especially E484K, K417T, and N501Y in the receptor-binding domain (RBD) of the spike protein): (i) some key substitutions may lead to the immunity e
Result: Fifteen substitutions (10 in the spike protein: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, and T1027I) are P.1 lineage-defining mutations (Figure 1B and Table 2).
Monitoring SARS-CoV-2 Populations in Wastewater by Amplicon Sequencing and Using the Novel Program SAM Refiner.
Result: Sequences from the RBD amplicon matched reference sequence, lineages B.1.1.7 with '1501T(N501Y) 1709A(A570D)', P.1 with '1250C(K417T) 1450A(E484K) 1501T(N501Y)', or had the single variations of T478K or L452R (Supplementary 11).
Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein.
PMID: 34463219
2021
Journal of biomolecular structure & dynamics
Method: Using the same PDB ID, the SARS-CoV-2 variants (N501Y, E484K, K417N/T, A475V,
Result: After determining the binding affinities of the chondramides towards point-mutated SARS-CoV-2 spike variants, the selected compounds were subjected to molecular docking against recently known strains with more than one amino acid substitutions in the spike RBD sequence namely, the South African variant (Wibmer et al.,) (N501Y-E484K-K417N) and the Brazilian variant (Nonaka et al., 2021) (N501Y-E484K-K417T).
Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants.
Method: We also used COVID-3D for the structural analysis of significant mutations (E484K, K417T/N, N501Y, and D614G) in emerging variants.
Result: Some significant mutations (E484K, K417T/N, N501Y, and D614G) found in emerging variants and t
Table: K417T
Figure: Structural landscape of the K417T mutation.
Discussion: We have also evaluated the structural landscape of several significant mutations (E484K, K417T/N, N501Y, and D614G) in the emerging variants.
SARS_CoV_2 mutation literature information.
PMID: 
2021
eLife
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