literature

SARS_CoV_2 mutation literature information.

Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants.

PMID: 34543625 2021 The Journal of biological chemistry

Discussion: For example, the triple mutant K417T/E484K/N501Y (Gamma variant) poses a serious threat with many factors, increased protein expression, increased activity and increased antibody escape potential favoring its emergence and persistence.

Discussion: For example, when the data in Table 5 is compared between the N501Y (Alpha variant), the triple mutant K417T/E484K/N501Y (Gamma variant) and the Wild-type, increase in ACE2 binding might be significantly determined by the N501Y mutation, since no significant differences were observed in the Kd of ACE2 binding between the N501Y and K417T/E484K/

Review of the mechanisms of SARS-CoV-2 evolution and transmission.

PMID: 34545334 2021 ArXiv

Introd

Introduction: A list of vaccine-escape (vaccine-breakthrough) mutations was tabulated in our early work, including S494P, Q493L, K417N, F490S, F486L, R403K, E484K, L452R, K417T, F490L, E484Q, and A475S.

Introduction: Indeed, Eli Lilly mAbs were taken off the market in March due to Beta [K417N, E484K, N501Y] and Gamma [K417T, E484K, N501Y] variants.

The in vitro and in vivo efficacy of CT-P59 against Gamma, Delta and its associated variants of SARS-CoV-2.

PMID: 34547629 2021 Biochemical and biophysical research communications

Introduction: In particular, three mutations (K417T, E484K, and N501Y) in RBD (Receptor Binding Domain) are common in Alpha (N501Y) and Beta (K417 N, E484K, and N501Y) which are associated with increased transmissibility, immune escape and pathogenicity.

Result: E484K (8.66-fold) and N501Y (5.49-fold) was less than 10-fold susceptible to CT-P59, but CT-P59 showed lower IC50 value (0.7-fold) against K417T.

Result: To investigate the therapeutic efficacy of CT-P59 against Gamma, Delta and Epsilon variants, we first evaluated the binding affinity of CT-P59 against

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants.

PMID: 34549975 2021 Journal of virology

Table: K417T

Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants.

PMID: 34550770 2021 Journal of virology

Method: Mutation K417T in the P.1 variant was altered to K471N to generate the structure of the B.1.351 S-RBD variant using the Prime modeling program of Schrodinger Suite.

E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies.

PMID: 34562851 2021 Journal of molecular graphics & modelling

Introduction: In the 501Y.V2 and 501Y.V3 variants, besides the N501Y mutation, two other mutations E484K and K417N (or K417T) occurred in RBD of the S protein, and it was revealed that the E484K mutation obviously enhances the binding affinity between RBD and hACE2.

Mutations of SARS-CoV-2 RBD May Alter Its Molecular Structure to Improve Its Infection Efficiency.

PMID: 34572486 2021 Biomolecules

Introduction: However, there have been several mutations reported in SARS-CoV-2 RBD, such as N501Y, L452R, S477N, E484K, A502S, N439K, S494P, T478K, K417N, and K417T.

Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay.

PMID: 34578382 2021 Viruses

Introduction: The VOC P.1, which harbors the mutations of concern S:K417T/E484K/N501Y among its lineage defining mutations, originated in the Amazonas state in mid-November and rapidly spread across Brazil and to over 50 countries globally.

Variants of SARS-CoV-2, their effects on infection, transmission and neutralization by vaccine-induced antibodies.

PMID: 34604978 2021 European review for medical and pharmacological sciences

Abstract: S477N, E484K, Q677H, E484Q, L452R, K417T, K417N and N501Y.

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil.

PMID: 34615860 2021 Nature communications

Introduction: The coincident emergence of N501Y, K417T/N and E484K mutations in Gamma (P.1) and Beta (B.1.351) is suggestive of convergent evolution.

Introduction: Whilst P.2 harbours no other lineage-specific spike mutations, Gamma (P.1) has additional RBD mutations, most notably K417T and N501Y.

Method: Custom Gamma (P.1) and Zeta (P.2) ASP assays were designed to identify lineage-specific and highly sensitive single-nucleotide polymorphisms (SNPs) S:K417T (Gamma, P.1) and ORF1a:L3468V (Zeta, P.2).

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