Introduction: The Gamma variants described in Brazil belonging to the lineage P.1 clade 20J also have the E484K mutation in addition to K417T and N501Y mutations in their RBD.
A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants.
Introduction: Most class I mAbs were largely disrupted by the K417N/T mutation and class II mAbs by the E484K mutation.
Introduction: The Beta and Gamma variants each has three mutation sites in common within the RBD region:K417N/T, E484K, and N501Y:which change their antigenic profiles.
Result: In contrast, P36-1B7, like the class I mAb CB6, was substantially impacted by the
Figure: (A) The epitope of P36-5D2 (purple) is highlighted on the surface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RBD-3M carrying K417T, E484K, and N501Y (cyan) (PDB: 7FJC).
Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data.
Result: Furthermore, for Cq over 25 no SARS-CoV-2 variant (K417N/T, E484K, and N501Y) sample was detected by RAT.
Result: Interestingly, from the three SARS-CoV-2 (K417N/T, E484K, and N501Y) positive samples for RAT, two of them presented a band of low intensity (Table 2) compared to SARS-CoV-2 samples with no mutations identified, which present a high-intensity band in the range 20>=Cq <25 (Table 1).
Result: When we evaluated these NPSs containing SARS-CoV-2 variants, we observed that the sensitivity of RAT decreased in the variants that carry K417N/T and E484K amino acid substitutions, even in samples with the lowest ranges of Cq (20 <= Cq <25).
Importation, circulation, and emergence of variants of SARS-CoV-2 in the South Indian state of Karnataka.
Introduction: Viruses of the lineage B.1 have acquired several other amino acid replacements in the Receptor Binding Domain of the Spike protein - specifically in the lineages which have been designated as VOCs, namely -B.1.1.7 (N501Y), B.1.351 (N501Y, E484K, K417T) and P.1 from the lineage B.1.1.28 (N501Y, E484K, K417T).
SARS_CoV_2 mutation literature information.
PMID: 
2021
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