literature

SARS_CoV_2 mutation literature information.

Pan-SARS neutralizing responses after third boost vaccination in non-human primate immunogenicity model.

PMID: 35101265 2022 Vaccine

Table: K417T

Discussion: The Beta and Gamma variants are the most resistant to monoclonal antibodies (mAbs) and convalescent plasma from SARS CoV-2-infected individuals, and the resistance profiles correspond to several deletions in the N-terminal domain and the K417N/T, E484K/Q, and N501Y mutations in the RBD of SARS-CoV-2 Spike protein.

Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.

PMID: 35093235 2022 Cell reports

Result: It appears L452R, E484K, and N501Y may promote use of ferret ACE2, while K417N/T may result in a greater reduction in ferret ACE2 usage relative to human ACE2.

Aggregation of high-frequency RBD mutations of SARS-CoV-2 with three VOCs did not cause significant antigenic drift.

PMID: 35032057 2022 Journal of medical virology

Introduction: Mutations such as N501Y, S477N, N439K, L452R, E484K, K417N, T478K, and K417T were observed in VOCs and VOIs, and these sites were listed as RBD high-frequency mutation sites, suggesting that these sites are mutation-prone.

Result: The neutralization results for the possible VOC single variants showed that the N501Y mutation escape the mAbs CB6 and 03-10D12-1C3, while the N501T substitution in the Alpha+N501T variant does not escape mAb 03-10D12-1C3 (Figure 5A); the mAbs BGB-DXP593, 05-9G11, MW07-LALA, AM128, AM180, and AbG3 were escaped by the

PMID: 35026305 2022 Journal of virological methods

Introduction: Notable spike (S) amino acid mutations are: HV69/70 deletion and P681H in B.1.1.7, K417N in B.1.351, and K417T in P.1.

Modeling SARS-CoV-2 spike/ACE2 protein-protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related human protein targets, for COVID-19 handling in the 3PM context.

PMID: 35013687 2022 The EPMA journal

Result: From an energetical point of view, the P.1 Japan/Brazil VoC, showing the three mutations N501Y_E484K_K417T at the RBD, has the highest binding affinity (- 21.37 kcal/mol or - 89.41 kJ/mol; Table 1) for ACE2 (increased of 4% with respect to the Wuhan spike RBD, - 20.51 kcal/mol or - 85.81 kJ/mol, Table 1), followed by the B.1.141-VoC showing the single N439K amino acid replacement at the RBD and the single mutant E484K firstly detected in the spike RBD of the P.1 Japan/Brazil VoC (Table 1).

Result: Indeed, it is possible to count a slight increase in the hydrophobic interactions within a

Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India.

PMID: 35000004 2022 Archives of virology

Result: Until December 2020, none of the samples exhibited the characteristic mutations (K417N/T, E484K, N501Y, T478K) found in the variants of concern that have been identified so far.

A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2.

PMID: 34990583 2022 Cell reports

Introduction: Given that the B.1.351 and P.1 strains harbor K417N/T, E484K, and N501Y mutations in the RBD domain, B.1.526 harbors E484K, and B.1.617.1 harbors L452R and E484Q (Figure S4C), we wanted to develop a D614G- and E484K/Q-specific bivalent vaccine.

Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants.

PMID: 34537361 2022 Clinical microbiology and infection

Discussion: The latter can be overcome by inclusion of a K417N/T-specific assay.

Discussion: The proposed algorithm uses SGTF as first discriminator, which could be considered a limitation but alternative strategies including the E484K/Q, L452R, P681R/H and H655Y or K417N/T mutations could be used to discriminate between variants without the requirement of the SGTF.

Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.

PMID: 34848355 2022 Infection, genetics and evolution

Table: K417T

Discussion: Notably, sub-haplotypes 2A_3 and 2B_1 had the mutations at K417T, and E484K in the spike was a small proportion in the high partly vaccinated rate group in May 2021, which was found to decrease neutralization of human immune serum and cause severe disease even in patients that have been previously infected.

The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction Perspective.

PMID: 34529328 2022 Chembiochem

Conclusion: The K417N, K417T mutations lead to long range weak N417(S) D30(ACE2) and T417(S) D30(ACE2) interactions.

Conclusion: To summarize, we offer a dissection of the explicit residue to residue intermolecular interactions resulting from the specific S477N, N501Y, K417N, K417T, E484K mutations in the receptor binding domain of the spike protein in the wild-type SARS-COV-2 virus that have led to the highly concerning B.1.160, B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and P.2 (zeta) variants.

Table: K417T

Browser Board

Co-occurred Entities

Filtrator