Longitudinal analysis of SARS-CoV-2 spike and RNA-dependent RNA polymerase protein sequences reveals the emergence and geographic distribution of diverse mutations.
PMID: 34801754
2022
Infection, genetics and evolution
Figure: C) The mutations associated with the Gamma variant of concern appeared together in mid-December 2020; all mutations except for T20N and K417T were present separately before the emergence of the variant.
Reduced sensitivity of the SARS-CoV-2 Lambda variant to monoclonal antibodies and neutralizing antibodies induced by infection and vaccination.
Introduction: Of the Beta variants, the AY.1 and AY.2 lineages contain a K417N mutation, and the Gamma variant contains a K417 T mutation.
Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 2021.
PMID: 34848355
2022
Infection, genetics and evolution
Table: K417T
Discussion: Notably, sub-haplotypes 2A_3 and 2B_1 had the mutations at K417T, and E484K in the spike was a small proportion in the high partly vaccinated rate group in May 2021, which was found to decrease neutralization of human immune serum and cause severe disease even in patients that have been previously infected.
The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction Perspective.
Conclusion: The K417N, K417T mutations lead to long range weak N417(S) D30(ACE2) and T417(S) D30(ACE2) interactions.
Conclusion: To summarize, we offer a dissection of the explicit residue to residue intermolecular interactions resulting from the specific S477N, N501Y, K417N, K417T, E484K mutations in the receptor binding domain of the spike protein in the wild-type SARS-COV-2 virus that have led to the highly concerning B.1.160, B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and P.2 (zeta) variants.
Table: K417T
Figure: K41
Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variants.
PMID: 34537361
2022
Clinical microbiology and infection
Discussion: The latter can be overcome by inclusion of a K417N/T-specific assay.
Discussion: The proposed algorithm uses SGTF as first discriminator, which could be considered a limitation but alternative strategies including the E484K/Q, L452R, P681R/H and H655Y or K417N/T mutations could be used to discriminate between variants without the requirement of the SGTF.
A comprehensive overview of identified mutations in SARS CoV-2 spike glycoprotein among Iranian patients.
Discussion: There was another sequence sampled from Shiraz in Oct 2020 that contained five specific mutations (D138Y, D614G, E484K, K417T, N501Y) as indicator of the Gamma variant (GR/501Y.V3 (P.1+P.1.x)) and was clustered along with the representative Gamma variant spike sequence in phylogenetic tree.
Molecular definition of severe acute respiratory syndrome coronavirus 2 receptor-binding domain mutations: Receptor affinity versus neutralization of receptor interaction.
Structural and functional insights into the major mutations of SARS-CoV-2 Spike RBD and its interaction with human ACE2 receptor.
PMID: 34955621
2022
Journal of King Saud University. Science
Introduction: Substitution mutations like D614G, N501Y, Y453F, N439K/R, P681H, K417N/T, and E484K, as well as deletion mutations like DeltaH69/V70 and Delta242-244 are the most common in the spike protein.
Introduction: The E484K mutation is present in the Beta variants, whereas the E484K and K417T mutations are present in the Gamma variants.
Proteolytic activation of SARS-CoV-2 spike protein.
Introduction: However, there are conflicting observations that E484K and K417N/T are mutations acquired to escape from neutralizing antibodies and rather reduce binding to ACE2.
Introduction: It does not have mutations found in the aforesaid three VOCs, such as N501Y, E484K, and K417N/T.
Introduction: The beta and gamma variants emerged in South Africa and Brazil, respectively, and in addition to N501Y, they have mutations, K417N/T and E484K, which may directly affect the interaction with ACE2, resulting in enhanced ACE2 binding (Figure 5).
Computational modelling of potentially emerging SARS-CoV-2 spike protein RBDs mutations with higher binding affinity towards ACE2: A structural modelling study.
PMID: 34979405
2022
Computers in biology and medicine
Introduction: These VOCs harbour numerous mutations in the RBD domain, which includes N501Y, E484K and K417 N/T.
SARS_CoV_2 mutation literature information.
PMID: 
2022
Infection, genetics and evolution
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