Result: 501.V2 includes the mutations L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, A701V.
Result: A newer variation of the Delta strain, AY.1 (or Delta+) does however contain the K417N mutation (that we predict to increase open state occupancy) similar to the South African strain 501.V2.
Result: However, mutations like K417N and K417T were not observed to cause favourable changes on expression (a proxy measurement for stability) or binding as well as immune recognition, but in our high throughput evaluation they were, as well as several substitutions in th
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies.
Result: The mutation E484K alone reduced sera neutralization capacity by 3.6-fold [ratio NT50 mutant/NT50 WT of 0.028+-0.37 (geometric mean +- SD)], and inclusion of additional mutations (K417N and N501Y) further decreased the neutralization (0.08+-0.05), emphasizing the role of synergic mutations on immune evasion and underscoring the need for evaluating si
Discussion: The fact that only mutations containing the E484K substitution promote immune escape, although this effect increases with synergic mutations that improve viral binding to ACE2 (K417N and N501Y), may be a consequence of lack in immunological selective pressure, a recognized driver of evolution, as a large proportion of the population remains susceptible to SARS-CoV-2 infection.
Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021.
Result: The Spike_K417N mutation was reported at 34.36% in SARS-CoV-2 genome sequences isolated from Africa.
Neutralizing Activity of Sera from Sputnik V-Vaccinated People against Variants of Concern (VOC: B.1.1.7, B.1.351, P.1, B.1.617.2, B.1.617.3) and Moscow Endemic SARS-CoV-2 Variants.
Result: The RBD variability data obtained for SARS-CoV-2 variants from Moscow patients (Figure 2, dashed lines) are generally consistent with the variability data for Russian sequences available in GISAID (Figure 2, solid lines and Figure S1) showing increasing prevalence of S477N, A522S, E484K, N501Y, T385I, S494P, N439K, K417N, T487K, N501T, and Y508H mutations.
Discus
Discussion: For the K417N mutation, a positive effect on the interaction with ACE2 and a weakened interaction with the neutralizing antibody STE90-C11 were shown.
SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India.
Introduction: These variants are known to possess multiple mutations across the genome, including several in the S protein and its RBD, such as N501Y, E484K and K417N/T.
Mutation hotspots and spatiotemporal distribution of SARS-CoV-2 lineages in Brazil, February 2020-2021.
Introduction: It has the same three mutations (except for K417T instead of K417N) in RBD as B.1.351, but it arose independently.
Introduction: The second (B.1.351) emerged in South Africa in October 2020 and harbor a constellation of mutations in the Receptor Binding Domain (RBD) (especially K417N, E484K, and N501Y).
Discussion: Molecular dynamic simulation reveals that E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 var
Droplet digital RT-PCR to detect SARS-CoV-2 signature mutations of variants of concern in wastewater.
PMID: 34371414
2021
The Science of the total environment
Abstract: It also indicates that RT-ddPCR could be used for sensitive and accurate monitoring of current (like K417N, K417T, E484K, L452R) or future mutations present in SARS-CoV-2 variants of concern.
Discussion: E484K, K417T, K417N or L452R) characteristic for various epidemiologically or immunologically relevant VoC's.
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.
Precision Response to the Rise of the SARS-CoV-2 B.1.1.7 Variant of Concern by Combining Novel PCR Assays and Genome Sequencing for Rapid Variant Detection and Surveillance.
Discussion: Assays that target S gene mutations such as E484K, K417N, K417T, L452R, the Y144 deletion, and the 242 to 244 deletion, and the ORF1ab gene 3675 to 3677 deletion, are in development.
GB-2 blocking the interaction between ACE2 and wild type and mutation of spike protein of SARS-CoV-2.
Discussion: A previous study suggested that the K417N mutation minimally affects this binding between the RBD and the ACE2 receptor.
Discussion: Because these N501Y, K417N, E484K and L452R mutations in RBD play the important role in immune evasion, we focused on the effect of GB-2 on these mutations.
Discussion: GB-2 can inhibit the binding between ACE2 and RBD with the triple mutation (K417N-E484K-N501Y).
Discussion: However, the combination of the E484K, K417N, and N501Y mutatio
SARS_CoV_2 mutation literature information.
PMID: 
2021
PLoS computational biology
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