literature

SARS_CoV_2 mutation literature information.

Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect.

PMID: 34472141 2021 Phytotherapy research

Abstract: These mutations were noticed to happen in the receptor-binding domain of spike protein (S-RBD), especially mutations N501Y, E484Q, E484K, K417N, K417T, and L452R.

Introduction: These lineages of viruses have many mutations in receptor-binding domain (RBD) of S1 subunit of SARS-CoV-2, especially mutations N501Y, E484Q, E484K, L452R, K417N, and K417T (Ostrov, ; Verghese et al., ).

Result: In addition, mutated amin

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.

PMID: 34478710 2021 The Journal of biological chemistry

Result: In 2021 sequences, most residues were still found to be >99% conserved except for variations found at residues 417 (K417N, 1.5%; K417T, 2.6%) and 501 (N501Y, 65.2%), with the latter becoming predominant among all the deposited sequences in 2021.

Result: These mutations are found in emergent variants of concern (VOCs), including the B.1.1.7 (N501Y), B.1.351 (K417N/N501Y), and P.1 lineages (K417T/N501Y).

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies.

PMID: 34484190 2021 Frontiers in immunology

Introduction: In addition, several recent studies have focused on the neutralizing activity of vaccine-elicited humoral immunity against new circulating mutant lineages, including B.1.1.7 (United Kingdom, bearing mutations 69-70 del, 144 del, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H in the spike protein), B.1.429 (United States, bearing mutations S13I, W152C, L452R, and D614G in the spike protein), B.1.351(South Africa, bearing mutations D80A, D215G,

PMID: 34488546 2021 Expert review of vaccines

Introduction: K417N was first reported in the RBD region of the Beta variant and can bind to N501Y, thus increasing the binding between spike proteins and ACE2 receptors in the variant and possibly reducing the susceptibility of the virus to neutralizing antibodies by more than 10 times.

Introduction: In addition to the three important mutation sites mentioned above, the Delta-AY.1 variant has the K417N mutation, which has potentially serious consequences.

Introduction: The Delta variant contains L452R, T478K, D614G, and P681R (Delta-AY.1 with additional K417N mutation) mutations in the S protein do

A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo.

PMID: 34495697 2021 Journal of virology

Abstract: Here, we report the generation and use of a recombinant (r)SARS-CoV-2 USA/WA1/2020 (WA-1) strain expressing Venus and an rSARS-CoV-2 strain expressing mCherry and containing mutations K417N, E484K, and N501Y found in the receptor binding domain (RBD) of the spike (S) glycoprotein of the South African (SA) B.1.351 (beta [beta]) VoC in bifluorescent-based assays to rapidly and accurately identify human monoclonal antibodies (hMAbs) able to neutralize both viral infections in vitro and in vivo.

Introduction: Using this strategy, we have successfully rescued Venus-and mCherry-expressing rSARS-CoV-2 USA/WA1/2020 (WA-1) and a new rSARS-CoV-2 strain expressing mCherry and containing mutations K417N,

PMID: 34495709 2021 Journal of clinical microbiology

Method: At that time, we customized the TaqMan assay to detect SARS-CoV-2 spike protein with the N501Y, E484K, K417N, and K417T mutations.

Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2).

PMID: 34495817 2021 Journal of biomolecular structure & dynamics

Method: Following the energy minimization, the control SARS-CoV-2 RBD/ACE2 and mutant (E484K, N501Y, K417N + E484K + N501Y) SARS-CoV-2 RBD/ACE2 protein-protein dockings were performed on the HADDOCK (High Ambiguity Driven protein-protein DOCKing) 2.4 docking server (De Vries et al.,).

Method: In this study, protein-protein complexes obtained from docking analysis with ACE2 of wild-type spike protein and other variants (E484K, N501Y and K417N + E484K + N501Y) were subjected to 200-ns molecular dynamics simulations to test the stability

Possible Link between Higher Transmissibility of Alpha, Kappa and Delta Variants of SARS-CoV-2 and Increased Structural Stability of Its Spike Protein and hACE2 Affinity.

PMID: 34502041 2021 International journal of molecular sciences

Introduction: In October 2020, B.1.351 (Beta variant) was detected in the South African population,

Discussion: After Alpha, the second main VOC detected was Beta in October 2020 in the South African population, and it had five main mutations, which were reported to be beneficial for transmission:L18F, K417N, E484K, N501Y and D614G.

Discussion: In a recent study, where 12 monoclonal antibodies were tested for their neutralizing activity against Alpha and Beta variants, it was found that N501Y of Alpha variant modulated interaction of neutralizing antibodies only, while in case of Beta, complete loss of activity was observed in most of the antibodies, mediated by K417N and E484K, in comparison to wildtype.

Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines.

PMID: 34508827 2021 Biochimie

Method: The chosen sequences of single mutations included the following amino acid substitutions: L5F, L18F, D80A, S98F, A222V, A262S, P272L, K417 N, N439K, L452R, Y453F, S477 N, E484K, E484Q, N501T, N501Y, E583D, D614G, Q675H, Q675P, Q677H,

PMID: 34513478 2021 Cureus

Introduction: Mutations in the Beta and Gamma variants, including E484K and K417N/T, are of high concern since they partly compromise neutralization generated by previous infection or vaccination or affect viral stability.

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