literature

SARS_CoV_2 mutation literature information.

Global Prevalence of Adaptive and Prolonged Infections' Mutations in the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein.

PMID: 34696404 2021 Viruses

Result: Additionally, mutations K417N, K417T, T470N, T478R, E484A, F490S and Q493K were observed.

Result: In our study, the highest prevalence of the K417N mutation was found in Finland (2/13 sequences), followed by the Philippines (8/71 sequences).

Result: The K417N/T mutation has been shown to have impaired ACE2 binding.

Evolution of SARS-CoV-2 Key Mutations in Vienna Detected by Large Scale Screening Program.

PMID: 34696444 2021 Viruses

Result: Detection of N501Y+/K417N+ cases were rather occasional events on two separate days, accounting for 1.7% and 0.4% of weekly cases.

Result: For all N501Y+ samples, we additionally analyzed the presence of the K417N (K417N+) and V1176F (V1176F+) mutations.

Result: We identified three samples that were positive for the K417N and the N501Y mutation (N501Y+/K417N+).

Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.

PMID: 34700382 2021 mBio

Result: A total of 139 unique S protein variants of beta (B.1.351) were clustered, with the majority carrying 7 consensus amino acid variations (D80A, D215G, K417N, E484K, N501Y, D614G, and A701V) and 1 deletion (amino acid 242).

Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity.

PMID: 34722330 2021 Frontiers in cellular and infection microbiology

Result: For this, we first constructed S genes expression vectors of N501Y.V1 variant (with all nine mutations) and N501Y.V2 RBD mutations (K417N, E484K, N501Y and D614G) ( Figure 1A ).

Discussion: Indeed, N501Y.V3 lineage includes three mutations in the RBD region (K417T, E484K and N501Y), and it almost has the same three mutations present in RBD as N501Y.V2 lineage, except for K417N/T substitution.

Discussion: r

Genomic surveillance reveals the detection of SARS-CoV-2 delta, beta, and gamma VOCs during the third wave in Pakistan.

PMID: 34726786 2021 Journal of medical virology

Introduction: Interestingly, the gamma and beta lineages share three common mutations (K417N/T, E484K, and N501Y) in spike protein.

Introduction: The K417N/T, E484K, and N501Y mutations significantly decreased the neutralizing activity of convalescent and messenger RNA vaccine-induced se

Introduction: The beta variant was first reported in South Africa in December, 2020 and is characterized by seven different lineage-defining mutations in the spike protein, with three significant mutations (N501Y, E484K, and K417N) in the receptor-binding domain (RBD).

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants.

PMID: 34732694 2021 Signal transduction and targeted therapy

Result: We investigated several RBD variants within publicly available SARS-CoV-2 sequences in the Global Initiative on Sharing All Influenza Data (GISAID) and all of the individual RBD mutants (N501Y, E484K, E484Q, K417N, K417T, L452R, L452Q, T478K) found in dominant VOCs (B.1.1.7, Alpha; B.1.352, Beta; P.1, Gamma; B.1.617.2, Delta; B.1.427/B.1.429, Epsilon) for n3113.1 binding.

SARS-CoV-2 Variants Detection Using TaqMan SARS-CoV-2 Mutation Panel Molecular Genotyping Assays.

PMID: 34737587 2021 Infection and drug resistance

Result: The B.1.351 control showed mutation in E484K, D614G, A701V, K417N, N501Y, and L242_244L, B.1.1.7 showed mutations in D614G, delH69V70, N501Y, and Q27stop, the control B.1.617.1 showed mutation in E484Q, P681R, L452R, D614G, and P.1 showed mutations in E484K, D614G, K417T, N501Y, and T20N.

Table: K417N

Discussion: Although

Molecular strategies for antibody binding and escape of SARS-CoV-2 and its mutations.

PMID: 34741079 2021 Scientific reports

Abstract: We found that the combination of mutations

Introduction: We benchmarked five hNAbs (two in Classes I and II and one in Class III) with the RBD, including three mutations N501Y (MT1), E484K, and N501Y (MT2), and K417N, E484K, and N501Y (MT3).

Method: To assess the ability of antibodies to link to mutated S-proteins, we used the recently reported mutation of the S-protein corresponding to MT1: N501Y, MT2: E484K/N501Y, and MT3: K417N/E484K/N501Y.

Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern.

PMID: 34746689 2021 iScience

Discussion: The K417N and E484K changes in the S1 RBD have been shown to contribute to escape from neutralizing antibodies.

Changing predominant SARS-CoV-2 lineages drives successive COVID-19 waves in Malaysia, February 2020 to March 2021.

PMID: 34757638 2021 Journal of medical virology

Discussion: To date, B.1.524 does not contain other spike mutations associated with increased pathogenicity or immune escape, such as K417N, L452R, E484K, and N501Y.

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